Skip to main content

Table 2 Base-case and sensitivity analysis results

From: Comparative cost analysis of cervical cancer screening programme based on molecular detection of HPV in Spain

Base-case results (women aged 35–65 years N = 7,263,529 women)
  AHPV HC2 Cobas 4800 Difference AHPV versus HC2 Difference AHPV versus Cobas 4800
Number of procedures performed according to HPV detection technology and assuming cervical cancer screening coverage of 70%
HPV 7,263,529 7,263,529 7,263,529
LBC 544,765 835,306 900,678 − 290,541 (− 35%) − 355,913 (− 40%)
Colposcopies 169,476 321,175 320,641 − 151,699 (− 47%) − 151,165 (− 47%)
Cost of performing the different procedures
HPV test cost € 231,052,857 € 231,052,857 € 231,052,857
LBC cost € 17,781,199 € 27,264,382 € 29,398,177 € − 9,483,263 € − 11,616,998
Colposcopy and biopsy cost € 33,931,900 € 64,270,348 € 64,163,515 € − 30,356,448 € − 30,249,615
Total cost € 282,747,877 € 322,587,588 € 324,614,490 € − 39,839,711 € − 41,866,613
Sensitivity analysis results
  Base-case value SA value Cost form entry in screening until first colposcopy was performed
AHPV HC2 Cobas 4800 Difference AHPV versus HC2 Difference AHPV versus Cobas 4800
Target population (36.3% coverage in private service) 7,263,529 women (Assuming a cervical cancer screening coverage of 70%) 4,626,868 women (Assuming a cervical cancer screening coverage of 44.6%) € 180,110,398 € 205,488,294 € 206,779,430 € − 25,377,896 € − 26,669,032
Transition probabilities (HPV positive)
AHPV versus HC2 AHPV: 7.5% AHPV: 10.3% [13] € 302,047,351 € 356,017,663 € − 53,970,312
HC2: 15.7% [13]
HC2: 11.5% AHPV: 7.2% [29] € 280,680,076 € 297,913,008 € − 17,232,932
HC2: 8.4% [29]
AHPV versus Cobas 4800 AHPV: 7.5% AHPV: 15.3% [12] € 336,510,697 € 415,158,005 € − 78,647,307
Cobas: 24.4% [12]
Cobas: 12.4% AHPV: 12.8% [30] € 319,279,024 € 341,214,134 € − 21,935,110
Cobas 14.6% [30]
LBC, colposcopy and biopsy costs Primary LBC: € 42.55 LBC: € 50.56 [31] € 295,564,919 € 345,298,601 € 347,822,501 € − 49,733,682 € − 52,257,582
Colposcopy + biopsy: € 200.11 Colposcopy + biopsy: € 249.99 [31]
LBC: € 18.31 [17] € 258,447,168 € 281,312,441 € 281,789,684 € − 22,865,273 € − 23,342,515
Colposcopy + biopsy: € 134.64 [17]
  1. AHPV, Aptima HPV Assay; HC2, Hybrid Capture 2 Assay; HPV, human papilloma virus; LBC, liquid-base cytology