Fig. 4

Patient Global Impression of Change (PGIC) at month 3 for integrated Elaris EM-I and Elaris EM-II by baseline disease severity subgroups. PGIC uses a 7-point scale ranging from 1 = very much improved through 7 = very much worse. p values were obtained from a logistic regression model: “very much” or “much improved/otherwise” = treatment + subgroup + treatment × subgroup. p values for between-group comparisons were obtained using a contrast within the subgroup from the logistic regression model. *p < 0.05. Green indicates placebo, purple indicates elagolix 150 mg QD, and orange indicates elagolix 200 mg BID. BID twice daily; DYS dysmenorrhea; DYSP dyspareunia; GnRH gonadotropin-releasing hormone; NARC narcotic/opioid; NMPP non-menstrual pelvic pain; NSAID non-steroidal anti-inflammatory drug; QD once daily