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Table 2 Characteristics and reproductive factors of BC patients by molecular subtypes

From: The distribution of reproductive risk factors disclosed the heterogeneity of receptor-defined breast cancer subtypes among Tanzanian women

Characteristics

Luminal-A (n = 117)

Luminal-B (n = 59)

HER-2 enriched (n = 29)

Triple-negative (n = 58)

p value

Age at diagnosis (years)a

48.78 ± 12.19

39.73 ± 6.40

41.76 ± 9.14

44.49 ± 10.81

0.001

Histological type, n (%)b

     

IDC-NST

105 (89.7)

55 (93.2)

26 (89.7)

46 (79.3)

0.012

ILC

3 (2.6)

0 (0)

1 (3.4)

9 (15.5)

 

MC

2 (1.7)

2 (3.4)

1 (3.4)

0 (0)

 

Others

7 (6)

2 (3.4)

1 (3.4)

3 (5.2)

 

TNM pathological stage, n (%)b

     

I

1 (0.9)

0 (0)

2 (6.9)

1 (1.7)

0.059

II

24 (20.5)

4 (6.8)

2 (6.9)

11 (19)

 

III

64 (54.7)

33 (55.9)

15 (51.7)

34 (58.6)

 

IV

28 (23.9)

22 (37.3)

10 (34.5)

12 (20.7)

 

Tumor laterality, n (%)b

     

Left

60 (51.3)

31 (52.5)

11(37.9)

25 (43.1)

0.377

Right

53 (45.3)

27 (45.8)

18 (62.1)

29 (50)

 

Bilateral

4 (3.4)

1 (1.7)

0 (0)

4 (6.9)

 

Menopausal status, n (%)b

     

Pre-menopause

38 (32.5)

41 (69.5)

16 (55.2)

24 (39.1)

0.001

Post-menopause

79 (67.5)

18 (30.5)

13 (44.8)

34 (60.9)

 

Family history of BC, n (%)b

     

Yes

25 (21.4)

12 (20.3)

4 (13.8)

14 (24.1)

0.734

No

92 (78.6)

47 (79.7)

25 (86.2)

44 (75.9)

 

Menarche, n (%)b

     

Early < 12 years old

5 (4.3)

3 (5.1)

2 (6.9)

1 (1.7)

0.802

Normal 13–14 years old

54 (46.1)

27 (45.7)

10 (34.5)

24 (41.4)

 

Late > 15 years old

58 (49.6)

9 (49.2)

17 (58.6)

33 (56.9)

 

Age at first full-term pregnancy, n (%)b

     

< 30 years old

75 (74.8)

46 (86.8)

21 (79.3)

43 (87.8)

0.145

≥ 30 years old

25 (25.2)

9 (13.2)

6 (20.7)

10 (12.2)

 

Parity, n (%)b

     

Nulliparous

17 (13.7)

4 (6.8)

2 (6.9)

5 (10.3)

0.103

1–2 Children

35 (30.8)

26 (44.1)

7 (24.1)

20 (33.8)

 

≥ 3 Children

65 (55.6)

29 (49.2)

20 (69)

33 (55.9)

 

Breast-feeding, n (%)b

     

Yes

96 (82.1)

40 (67.8)

22 (75.9)

38 (65.5)

0.058

No

21 (17.9)

19 (32.2)

7 (24.1)

20 (25.5)

 

Breast-feeding duration, n (%)b

     

< 15 months

19 (19.8)

10 (25)

6 (27.3)

12 (31.6)

0.516

≥ 15 months

77 (80.2)

30 (75)

16 (72.7)

26 (68.4)

 
  1. The p-values less than 0.05 (typically ≤ 0.05) as being statistically significant and were bolded
  2. TNM tumor node metastasis, HER2 human epidermal growth factor receptor-2, IDC-NST invasive ductal carcinoma of no specific type, ILC invasive lobular carcinoma, MC mucinous carcinoma
  3. aThe values are calculated using one-way ANOVA and the data are given mean ± standard deviation
  4. bThe values are calculated using Chi-square test and the data are expressed in percentages. In all cases, differences were considered significant at p < 0.05