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Table 2 Correlation between the number of biopsies and the diagnosis of CIN2+ for all women, women without any visible changes of the cervix and women who underwent LEEP

From: Can biopsies be omitted after normal colposcopy in women referred with low-grade cervical cytology? A prospective cohort study

Diagnosis Biopsy 1 Biopsy 1 + 2 Biopsy 1 + 2 + 3 Biopsy 1 + 2 + 3 + 4
n % (95%CI) n % (95%CI) n % (95%CI) n % (95%CI)
All included women (n = 173)
No dysplasia 121 69.9 (62.5–76.7) 102 59.0 (51.2–66.4) 91 52.6 (44.9–60.2) 76 43.9 (36.4–51.7)
CIN1 33 19.1 (13.5–25.7) 44 25.4 (19.1–32.6) 52 30.1 (23.3–37.5) 59 34.1 (27.1–41.7)
CIN2+ 19 11.0 (6.7–16.6) 27 15.6 (10.5–21.9) 30 17.3 (12.0–23.8) 38 22.0 (16.0–28.9)
Women without any visible changes of the cervix (n = 137)
No dysplasia 100 73.0 (64.7–80.2) 85 62.0 (53.4–70.2) 76 55.5 (46.7–64.0) 65 47.4 (38.9–56.1)
CIN1 27 19.7 (13.4–27.4) 37 27.0 (19.8–35.3) 45 32.8 (25.1–41.4) 50 36.5 (28.4–45.1)
CIN2+ 10 7.3 (3.6–13.0) 15 10.9 (6.3–17.4) 16 11.7 (6.8–18.3) 22 16.1 (10.3–23.3)
Women who underwent LEEP (n = 21)
No dysplasia 5 23.8 (8.2–47.2) 3 14.3 (3.0–36.3) 3 14.3 (3.0–36.3) 0 0.0 (0–16.1)
CIN1 6 28.6 (11.3–52.2) 4 19.0 (5.4–41.9) 3 14.3 (3.0–36.3) 3 14.3 (3.0–36.3)
CIN2+ 10 47.6 (25.7–70.2) 14 66.7 (43.0–85.4) 15 71.4 (47.8–88.7) 18 85.7 (63.7–97.0)
  1. CIN1, Cervical intraepithelial neoplasia grade 1; CIN2+, cervical intraepithelial neoplasia grade 2 or worse; LEEP, loop electrosurgical excision procedure