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Table 2 Association of genotypes related to POI with lipid profile in target population divided into POI cases and healthy controls

From: The relationship between genetic variants associated with primary ovarian insufficiency and lipid profile in women recruited from MASHAD cohort study

Polymorphisms

POI cases (N = 117)

Controls (N = 183)

rs16991615

AA

GA

GG

P

AA

GA

GG

P

Serum total cholesterol (mg/dl)

222.3 ± 41.4a

195.8 ± 35.3b

209.4 ± 29.5ab

0.01

190.2 ± 33.8

191.2 ± 33.5

186.4 ± 32.7

0.64

Triglyceride (mg/dl)

108.0

(78.0–181.0)

112.0

(82.0–147.0)

107.0

(89.0–156.0)

0.96

98.5

(65.8–121.3)

129.0

(87.0–159.0)

108.0

(79.5–162.3)

0.14

HDL (mg/dl)

48.6 ± 7.7

45.9 ± 8.9

48.0 ± 10.5

0.44

45.0

(40.8–53.0)

44.0

(35.0–53.0)

43.0

(35.6–54.3)

0.58

LDL (mg/dl)

136.1 ± 37.8

120.3 ± 29.9

130.6 ± 34.1

0.15

116.7 ± 35.2

112.7 ± 34.0

107.1 ± 32.5

0.39

rs244715

GG

AG

AA

P

GG

AG

AA

P

Serum total cholesterol (mg/dl)

213.3 ± 44.4ab

216.7 ± 35.5a

198.8 ± 32.3b

0.04

185.8 ± 25.8

182.9 ± 29.2

192.1 ± 35.0

0.21

Triglyceride (mg/dl)

140.5

(77.5–202.7)

112.0

(85.0–179.0)

108.0

(82.7–151.5)

0.75

107.0

(84.0–231.3)

122.0

(85.5–163.5)

113.0

(77.0–149.5)

0.55

HDL (mg/dl)

46.3 ± 8.6

47.8 ± 8.2

47.4 ± 10.5

0.88

43.5

(33.8–49.3)

42.0

(36.3–55.7)

44.0

(35.6–52.9)

0.93

LDL (mg/dl)

126.8

(111.9–158.8)

134.4

(115.9–146.5)

124.1

(93.1–142.6)

0.18

96.1 ± 36.4ab

97.2 ± 34.3a

118.2 ± 30.5b

 < 0.001

rs451417

AA

CA

CC

P

AA

CA

CC

P

Serum total cholesterol (mg/dl)

201.0

(191.0–236.0)

207.5

(178.0–231.7)

208.5

(181.2–223.2)

0.71

194.5

(174.0–211.5)

181.5

(164.5–201.5)

192.0

(162.0–217.0)

0.31

Triglyceride (mg/dl)

120.0

(82.0–185.0)

111.5

(78.3–153.0)

107.5

(84.5–151.5)

0.51

106.0

(88.3–144.0)

124.0

(77.3–166.5)

115.0

(80.0–154.0)

0.94

HDL (mg/dl)

47.5 ± 9.1

46.2 ± 9.0

48.4 ± 9.8

0.56

45.5

(39.3–54.4)

43.5

(34.3–54.5)

42.8

(36.6–52.1)

0.78

LDL (mg/dl)

132.3 ± 38.3

122.0 ± 29.8

130.7 ± 33.9

0.39

117.4 ± 28.9

104.7 ± 34.1

113.9 ± 33.3

0.14

rs1046089

AA

GA

GG

P

AA

GA

GG

P

Serum total cholesterol (mg/dl)

196.0

(177.0–225.0)

207.0

(184.0–232.0)

209.0

(186.5–224.5)

0.76

177.1 ± 23.4

192.5 ± 33.1

188.0 ± 35.0

0.13

Triglyceride (mg/dl)

112.0

(79.0–214.0)

112.0

(82.0–153.0)

109.0

(84.0–154.5)

0.87

112.0

(80.0–155.0)

118.0

(84.0–162.5)

117.0

(76.0–159.0)

0.55

HDL (mg/dl)

50.4 ± 7.7

47.4 ± 9.4

46.6 ± 9.7

0.49

52.0

(40.0–58.0)a

45.0

(34.0–55.0)ab

43.0

(35.1–50.0)b

0.03

LDL (mg/dl)

122.5 ± 40.1

127.2 ± 32.8

132.2 ± 34.7

0.65

75.5

(58.6–111.0)a

108.0

(87.1–137.0)b

122.5

(101.1–138.6)bc

 < 0.001

rs7246479

AA

TA

TT

P

AA

TA

TT

P

Serum total cholesterol (mg/dl)

201.5

(196.3–233.5)

200.5

(176.0–225.5)

213.0

(200.0–234.0)

0.12

178.6 ± 21.3

187.2 ± 31.8

191.3 ± 35.1

0.48

Triglyceride (mg/dl)

101.5

(73.3–167.0)

108.0

(81.3–150.7)

118.0

(94.0–186.0)

0.29

145.0

(93.5–164.3)

118.5

(84.7–152.3)

107.0

(77.0–161.0)

0.63

HDL (mg/dl)

48.7 ± 7.1

47.6 ± 9.2

46.8 ± 10.4

0.83

53.5

(41.5–57.7)

44.0

(35.0–52.5)

42.8

(36.0–53.1)

0.26

LDL (mg/dl)

137.9 ± 31.2

123.8 ± 30.7

133.6 ± 39.8

0.23

82.6 ± 29.4a

107.8 ± 33.9ab

115.5 ± 32.0b

0.02

rs4806660

CC

TC

TT

P

CC

TC

TT

P

Serum total cholesterol (mg/dl)

200.6 ± 34.8ab

217.0 ± 34.3a

199.8 ± 35.9b

0.04

161.4 ± 25.1

189.1 ± 33.2

190.6 ± 32.9

0.08

Triglyceride (mg/dl)

93.5

(73.3–168.0)ab

122.0

(97.5–183.5)a

100.0

(73.0–140.0)b

0.02

133.0

(100.0–167.0)

111.5

(80.7–160.5)

117.0

(76.7–156.0)

0.66

HDL (mg/dl)

53.5 ± 12.3a

44.9 ± 8.0b

48.7 ± 9.0ab

0.01

46.0

(40.0–56.0)

43.7

(35.5–54.3)

43.2

(35.7–52.5)

0.82

LDL (mg/dl)

112.2 ± 32.9

134.7 ± 34.9

125.6 ± 32.1

0.08

73.1 ± 26.1a

104.3 ± 33.0b

118.6 ± 31.4c

 < 0.001

rs10183486

TT

CT

CC

P

TT

CT

CC

P

Serum total cholesterol (mg/dl)

197.7 ± 27.7ab

199.3 ± 34.6a

220.1 ± 35.9b

0.01

193.9 ± 35.3

192.4 ± 36.5

185.2 ± 29.5

0.32

Triglyceride (mg/dl)

97.5

(74.7–119.5)

107.5

(80.7–150.7)

122.0

(94.0–185.0)

0.12

143.0

(91.0–180.5)

111.0

(77.5–144.0)

120.0

(82.5–164.5)

0.23

HDL (mg/dl)

47.2 ± 6.4

47.7 ± 11.2

47.2 ± 7.5

0.95

35.5

(31.4–39.3)a

44.0

(39.0–54.5)b

43.5

(34.0–53.3)bc

0.02

LDL (mg/dl)

118.9 ± 25.1ab

119.5 ± 31.1a

140.9 ± 35.5b

0.003

120.5 ± 29.3

114.4 ± 34.3

106.1 ± 32.7

0.17

rs2303369

TT

CT

CC

P

TT

CT

CC

P

Serum total cholesterol (mg/dl)

206.5 ± 29.7

213.6 ± 36.8

200.8 ± 36.5

0.23

181.9 ± 19.6

192.6 ± 32.8

185.9 ± 35.3

0.19

Triglyceride (mg/dl)

98.0

(69.0–129.0)

117.0

(94.5–182.0)

106.0

(77.5–152.0)

0.05

106.0

(75.0–150.0)

120.0

(84.5–162.3)

117.0

(76.0–154.5)

0.36

HDL (mg/dl)

52.0 ± 10.1a

44.6 ± 8.5b

48.9 ± 9.1ab

0.01

56.5

(49.8–60.8)a

44.5

(34.0–55.0)b

42.8

(35.3–48.7)bc

0.002

LDL (mg/dl)

117.6

(100.9–139.6)

134.4

(116.3–149.0)

123.6

(103.1–147.8)

0.14

85.8 ± 27.6a

109.7 ± 32.2b

117.1 ± 33.2bc

0.001

  1. Statistically significant values are shown in bold
  2. POI: Primary Ovarian Insufficiency; HDL: High-Density Lipoprotein; LDL: Low Density Lipoprotein; One-way analysis of variance (ANOVA) OR Kruskal–Wallis tests were used;  Significant P value < 0.05