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Table 4 Investigation of the relationship between the risk of polymorphisms related to Primary Ovarian Insufficiency and dyslipidemia factors in the study population in an adjusted model for age and physical activity level

From: The relationship between genetic variants associated with primary ovarian insufficiency and lipid profile in women recruited from MASHAD cohort study

Polymorphisms

Lipid profile abnormalities

POI cases

Control

OR (95% CI)

P

OR (95% CI)

P

OR (95% CI)

P

OR (95% CI)

P

rs16991615

GA/AA

GG/AA

GA/AA

GG/AA

High LDL (mg/dl)

0.63 (0.23, 1.72)

0.36

1.21 (0.46, 3.17)

0.69

0.67 (0.22, 2.04)

0.48

0.37 (0.12, 1.15)

0.08

High Triglyceride (mg/dl)

0.45 (0.15, 1.38)

0.16

0.84 (0.30, 2.33)

0.74

1.38 (0.34, 5.53)

0.64

1.69 (0.43, 6.61)

0.45

Low HDL (mg/dl)

1.37 (0.50, 3.76)

0.54

1.05 (0.40, 2.76)

0.91

0.63 (0.19, 2.05)

0.45

0.59 (0.18, 1.89)

0.38

High Total Cholesterol (mg/dl)

0.34 (0.12, 0.99)

0.04

0.91 (0.32, 2.57)

0.86

0.67 (0.22, 2.02)

0.48

0.55 (0.18, 1.65)

0.29

rs244715

AG/GG

AA/GG

AG/GG

AA/GG

High LDL (mg/dl)

2.13 (0.58, 7.82)

0.25

1.02 (0.28, 3.69)

0.96

1.18 (0.12, 11.32)

0.88

3.11 (0.34, 27.94)

0.31

High Triglyceride (mg/dl)

0.39 (0.10, 1.48)

0.17

0.36 (0.09, 1.36)

0.13

1.44 (0.23, 8.86)

0.69

0.74 (0.12, 4.44)

0.75

Low HDL (mg/dl)

0.60 (0.15, 2.30)

0.46

0.78 (0.21, 2.96)

0.72

0.48 (0.05, 4.45)

0.52

0.39 (0.04, 3.53)

0.41

High Total Cholesterol (mg/dl)

1.88 (0.50, 7.04)

0.35

0.76 (0.21, 2.72)

0.68

0.68 (0.11, 4.21)

0.68

1.28 (0.22, 7.38)

0.78

rs451417

CA/AA

CC/AA

CA/AA

CC/AA

High LDL (mg/dl)

1.27 (0.47, 3.42)

0.63

1.80 (0.71, 4.58)

0.21

0.52 (0.17, 1.55)

0.24

0.99 (0.35, 2.83)

0.99

High Triglyceride (mg/dl)

0.57 (0.19, 1.63)

0.29

0.51 (0.18, 1.39)

0.19

1.84 (0.54, 6.30)

0.32

1.34 (0.39, 4.60)

0.64

Low HDL (mg/dl)

1.18 (0.43, 3.22)

0.74

0.91 (0.36, 2.32)

0.85

0.72 (0.24, 2.10)

0.55

1.09 (0.37, 3.18)

0.87

High Total Cholesterol (mg/dl)

0.86 (0.31, 2.35)

0.77

1.06 (0.41, 2.73)

0.89

0.56 (0.19, 1.60)

0.28

0.84 (0.30, 2.35)

0.75

rs1046089

GA/AA

GG/AA

GA/AA

GG/AA

High LDL (mg/dl)

2.52 (0.61, 10.45)

0.20

3.62 (0.82, 16.09)

0.09

3.64 (0.75,17.59)

0.10

5.89 (1.22, 28.34)

0.02

High Triglyceride (mg/dl)

0.45 (0.11, 1.71)

0.24

0.59 (0.14, 2.42)

0.47

0.64 (0.21, 1.92)

0.42

0.46 (0.15, 1.45)

0.18

Low HDL (mg/dl)

1.72 (0.47, 6.25)

0.41

2.31 (0.58, 9.15)

0.23

1.33 (0.48, 3.67)

0.58

2.42 (0.85, 6.84)

0.09

High Total Cholesterol (mg/dl)

1.90 (0.52, 6.92)

0.33

2.26 (0.57, 8.93)

0.24

1.75 (0.55, 5.53)

0.33

1.53 (0.48, 4.88)

0.47

rs7246479

TA/AA

TT/AA

TA/AA

TT/AA

High LDL (mg/dl)

0.45 (0.12, 1.62)

0.22

1.47 (0.37, 5.78)

0.58

1.97 (0.22, 17.75)

0.54

2.42 (0.26, 22.31)

0.43

High Triglyceride (mg/dl)

0.96 (0.22, 4.12)

0.96

2.27 (0.50, 10.30)

0.28

0.15 (0.02, 0.88)

0.03

0.15 (0.02, 0.95)

0.04

Low HDL (mg/dl)

1.37 (0.39, 4.77)

0.61

1.65 (0.43, 6.30)

0.45

4.27 (0.75, 24.30)

0.10

5.79 (0.98, 33.99)

0.05

High Total Cholesterol (mg/dl)

0.51 (0.14, 1.91)

0.32

1.74 (0.40, 7.41)

0.45

0.99 (0.17, 5.59)

0.99

1.14 (0.19, 6.62)

0.88

rs4806660

TC/CC

TT/CC

TC/CC

TT/CC

High LDL (mg/dl)

2.64 (0.68, 10.16)

0.15

1.56 0.40, 6.14)

0.52

–

–

–

–

High Triglyceride (mg/dl)

1.55 (0.35, 6.76)

0.55

0.70 (0.15, 3.24)

0.65

0.44 (0.08, 2.44)

0.35

0.32 (0.06, 1.77)

0.19

Low HDL (mg/dl)

6.91 (1.61, 29.50)

0.01

3.32 (0.78, 14.17)

0.10

0.62 (0.10, 3.66)

0.60

0.60 (0.10, 3.50)

0.57

High Total Cholesterol (mg/dl)

1.95 (0.51, 7.45)

0.32

0.55 (0.14, 2.11)

0.39

–

–

–

–

rs10183486

CT/TT

CC/TT

CT/TT

CC/TT

High LDL (mg/dl)

0.68 (0.18, 2.54)

0.57

2.36 (0.63, 8.86)

0.20

2.01 (0.38, 10.70)

0.41

1.29 (0.24, 6.85)

0.76

High Triglyceride (mg/dl)

1.68 (0.31, 8.92)

0.54

3.51 (0.67, 18.40)

0.13

0.35 (0.08, 1.49)

0.15

0.66 (0.16, 2.73)

0.57

Low HDL (mg/dl)

0.62 (0.16, 2.38)

0.49

0.82 (0.21, 3.20)

0.77

0.26 (0.3, 2.22)

0.22

0.21 (0.02, 1.84)

0.16

High Total Cholesterol (mg/dl)

1.43 (0.39, 5.21)

0.58

4.43 (1.14, 17.16)

0.03

1.32 (0.29, 5.83)

0.71

0.81 (0.18, 3.57)

0.78

rs2303369

CT/TT

CC/TT

CT/TT

CC/TT

High LDL (mg/dl)

2.21 (0.74, 6.60)

0.15

1.24 (0.39, 3.87)

0.71

4.77 (0.57, 39.79)

0.15

7.48 (0.90, 61.75)

0.06

High Triglyceride (mg/dl)

3.22 (0.81, 12.85)

0.09

1.95 (0.46, 8.17)

0.36

0.89 (0.24, 3.35)

0.87

0.65 (0.17, 2.49)

0.53

Low HDL (mg/dl)

6.19 (1.93, 19.88)

0.002

2.39 (0.74, 7.66)

0.14

4.03 (1.12, 14.48)

0.03

7.97 (2.19, 28.96)

0.002

High Total Cholesterol (mg/dl)

0.68 (0.20, 2.27)

0.54

0.27 (0.07, 0.93)

0.03

2.12 (0.52, 8.55)

0.28

1.72 (0.42, 6.93)

0.44

  1. Statistically significant values are shown in bold
  2. Binary logistic regression models were performed; POI: Primary Ovarian Insufficiency; LDL: Low-Density Lipoprotein; HDL: High-Density Lipoprotein; High LDL > 130 and Normal LDL < 130; High Triglyceride > 150 and Normal Triglyceride < 150; Low HDL < 40 (Male) or < 50 (Female) and Normal HDL > 40 (Male) or > 50 (Female), High Total Cholesterol > 200 and Normal Total Cholesterol < 200; Normal groups of all lipid profile measures were considered as references; The common genotypes of each studied variants were considered as references; Adjusted with Age & Physical Activity Level; Significant P-value < 0.05
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