The relationship between genetic variants associated with primary ovarian insufficiency and lipid profile in women recruited from MASHAD cohort study

Table 5 Association of different genotypes related to POI with lipid profile in target population divided into POI cases and healthy controls

Polymorphisms
rs16991615	AA			GA			GG
	POI cases (N = 48)	Controls (N = 86)	P	POI cases (N = 40)	Controls (N = 79)	P	POI cases (N = 29)	Controls (N = 18)	P
Serum total cholesterol (mg/dl)	207.00 (50.00)	190.00 (57.00)	0.020	195.79 ± 35.28	191.16 ± 33.51	0.489	209.40 ± 29.54	186.42 ± 32.73	< 0.001
Triglyceride (mg/dl)	108.00 (103.00)	98.50 (56.00)	0.187	112.00 (65.00)	129.00 (72.00)	0.286	107.00 (67.00)	108.00 (83.00)	0.785
HDL (mg/dl)	48.62 ± 7.73	46.92 ± 8.39	0.489	45.94 ± 8.94	44.59 ± 12.12	0.538	48.00 (13.80)	43.00 (18.68)	0.120
LDL (mg/dl)	136.10 ± 37.79	116.74 ± 35.22	0.091	120.32 ± 29.94	112.70 ± 34.01	0.236	130.64 ± 34.13	107.10 ± 32.51	< 0.001

rs244715	GG			AG			AA
	POI cases (N = 56)	Controls (N = 116)	P	POI cases (N = 49)	Controls (N = 61)	P	POI cases (N = 12)	Controls (N = 6)	P
Serum total cholesterol (mg/dl)	213.33 ± 44.41	185.83 ± 25.77	0.183	211.00 (35.00)	182.00 (40.00)	< 0.001	198.81 ± 32.30	192.13 ± 35.05	0.237
Triglyceride (mg/dl)	140.50 (125.00)	107.00 (147.00)	0.779	112.00 (94.00)	122.00 (78.00)	0.683	108.00 (69.00)	113.00 (73.00)	0.937
HDL (mg/dl)	46.30 ± 8.58	42.83 ± 8.56	0.430	48.00 (12.00)	42.00 (19.40)	0.114	47.37 ± 10.48	44.92 ± 11.33	0.181
LDL (mg/dl)	132.17 ± 39.17	96.13 ± 36.42	0.078	134.40 (30.59)	102.09 (50.51)	< 0.001	121.72 ± 32.17	118.16 ± 30.53	0.487

rs451417	AA			CA			CC
	POI cases (N = 48)	Controls (N = 87)	P	POI cases (N = 36)	Controls (N = 76)	P	POI cases (N = 33)	Controls (N = 20)	P
Serum total cholesterol (mg/dl)	201.00 (45.00)	194.50 (38.00)	0.038	203.28 ± 33.02	183.95 ± 33.74	0.024	205.24 ± 33.68	192.12 ± 33.95	0.005
Triglyceride (mg/dl)	120.00 (103.00)	106.00 (56.00)	0.435	111.50 (75.00)	124.00 (89.00)	0.815	107.50 (67.00)	115.00 (74.00)	0.619
HDL (mg/dl)	47.46 ± 9.07	46.01 ± 8.85	0.576	46.19 ± 9.01	45.19 ± 12.64	0.632	48.65 (13.30)	42.80 (15.50)	0.040
LDL (mg/dl)	132.29 ± 38.32	117.44 ± 28.86		122.02 ± 29.80	104.74 ± 34.13		130.73 ± 33.94	113.86 ± 33.33

rs1046089	AA			GA			GG
	POI cases (N = 37)	Controls (N = 71)	P	POI cases (N = 69)	Controls (N = 89)	P	POI cases (N = 11)	Controls (N = 23)	P
Serum total cholesterol (mg/dl)	196.00 (48.00)	178.00 (40.00)	0.038	208.08 ± 36.16	192.53 ± 33.14	0.006	207.86 ± 35.61	188.02 ± 35.04	0.006
Triglyceride (mg/dl)	196.00 (48.00)	178.00 (40.00)	0.439	208.08 ± 36.16	192.53 ± 33.14	0.214	207.86 ± 35.61	188.02 ± 35.04	0.906
HDL (mg/dl)	50.41 ± 7.72	50.65 ± 11.57	0.952	47.80 (11.75)	45.00 (21.00)	0.195	46.90 (11.65)	43.00 (14.90)	0.090
LDL (mg/dl)	122.53 ± 40.11	85.01 ± 30.07	0.005	127.19 ± 32.75	109.64 ± 32.47	0.001	132.22 ± 34.72	119.75 ± 31.49	0.062

rs7246479	AA			TA			TT
	POI cases (N = 36)	Controls (N = 89)	P	POI cases (N = 67)	Controls (N = 86)	P	POI cases (N = 14)	Controls (N = 8)	P
Serum total cholesterol (mg/dl)	213.75 ± 34.18	178.63 ± 21.30	0.019	201.86 ± 33.72	187.20 ± 31.81	0.007	216.94 ± 38.71	191.34 ± 35.06	0.001
Triglyceride (mg/dl)	101.50 (94.00)	145.00 (71.00)	0.427	108.00 (70.00)	118.50 (68.00)	0.420	118.00 (92.00)	107.00 (84.00)	0.144
HDL (mg/dl)	48.69 ± 7.12	50.75 ± 9.96	0.596	47.56 ± 9.17	45.18 ± 11.67	0.161	47.80 (13.10)	42.80 (17.15)	0.258
LDL (mg/dl)	137.98 ± 31.21	82.58 ± 29.38	0.001	123.89 ± 30.71	107.86 ± 33.90	0.003	134.80 (36.18)	120.00 (41.54)	0.016

rs4806660	CC			TC			TT
	POI cases (N = 50)	Controls (N = 94)	P	POI cases (N = 53)	Controls (N = 82)	P	POI cases (N = 14)	Controls (N = 7)	P
Serum total cholesterol (mg/dl)	200.58 ± 34.85	161.43 ± 25.05	0.019	211.00 (35.00)	188.00 (36.00)	< 0.001	199.80 ± 35.90	190.63 ± 32.89	0.128
Triglyceride (mg/dl)	114.67 ± 59.99	132.71 ± 34.67	0.479	122.00 (86.00)	11.50 (80.00)	0.132	100.00 (67.00)	117.00 (79.00)	0.244
HDL (mg/dl)	53.50 ± 12.28	46.71 ± 9.32	0.225	46.85 (10.15)	43.75 (18.78)	0.860	48.70 ± 9.05	44.70 ± 11.72	0.039
LDL (mg/dl)	112.22 ± 32.96	73.08 ± 26.05	0.016	133.05 (34.01)	105.40 (52.35)	< 0.001	125.64 ± 32.13	118.66 ± 31.37	0.213

rs10183486	TT			CT			CC
	POI cases (N = 47)	Controls (N = 93)	P	POI cases (N = 55)	Controls (N = 81)	P	POI cases (N = 15)	Controls (N = 9)	P
Serum total cholesterol (mg/dl)	197.67 ± 27.73	193.96 ± 35.32	0.790	199.31 ± 34.62	192.44 ± 36.45	0.276	220.13 ± 35.86	185.20 ± 29.52	< 0.001
Triglyceride (mg/dl)	102.92 ± 40.22	142.11 ± 54.65	0.073	107.50 (70.00)	111.00 (67.00)	0.973	122.00 (91.00)	120.00 (82.00)	0.494
HDL (mg/dl)	47.18 ± 6.38	36.35 ± 8..69	0.004	47.40 (13.72)	44.00 (15.50)	0.564	47.80 (11.40)	43.50 (19.30)	0.132
LDL (mg/dl)	118.99 ± 25.14	120.46 ± 29.33	0.903	119.54 ± 31.13	114.42 ± 34.31	0.380	138.20 (37.90)	106.10 (47.60)	< 0.001

rs2303369	TT			CT			CC
	POI cases (N = 42)	Controls (N = 77)	P	POI cases (N = 54)	Controls (N = 90)	P	POI cases (N = 21)	Controls (N = 16)	P
Serum total cholesterol (mg/dl)	206.47 ± 29.72	181.88 ± 19.56	0.008	213.64 ± 36.80	192.59 ± 32.84	0.001	200.85 ± 36.50	185.90 ± 35.28	0.032
Triglyceride (mg/dl)	106.47 ± 52.80	108.38 ± 43.58	0.909	117.00 (88.00)	120.00 (78.00)	0.446	106.00 (75.00)	117.00 (79.00)	0.735
HDL (mg/dl)	52.01 ± 10.13	54.68 ± 11.40	0.466	45.00 (10.05)	44.50 (21.00)	0.937	48.80 (12.10)	42.80 (13.35)	0.001
LDL (mg/dl)	117.45 ± 29.31	82.78 ± 27.60	0.001	134.40 (32.72)	108.04 (48.80)	0.001	124.88 ± 33.16	117.08 ± 33.22	0.227

Statistically significant values are shown in bold
POI: Primary Ovarian Insufficiency; HDL: High-Density Lipoprotein; LDL: Low Density Lipoprotein; T-Student Test or Mann Whitney Test were used; Significant P value < 0.05

ISSN: 1472-6874