Table 2 Association between fatal stroke occurrence and age at menarche in the GBCS

Total cohort

1368

2662

2849

2787

2667

1720

2451

No. of deaths

14 (0.010)

28 (0.011)

28 (0.010)

25 (0.009)

39 (0.015)

37 (0.022)

51 (0.021)

Model 1

(HR, 95% CI)

1.22 (0.64–2.35), P = 0.55

1.19 (0.70–2.05), P = 0.52

1.13 (0.66–1.94), P = 0.66

1.00

1.63 (0.99–2.69), P = 0.06

2.39 (1.44–3.97), P = 0.001

2.34 (1.45–3.77), P = 0.001

Model 2

(HR, 95% CI)

1.86 (0.96–3.60), P = 0.07

1.69 (0.98–2.92), P = 0.06

1.41 (0.82–2.42), P = 0.22

1.00

1.41 (0.85–2.34), P = 0.18

1.83 (1.10–3.05), P = 0.02

1.66 (1.03–2.70), P = 0.04

Born < 1940^$ cohort

261

511

669

898

887

677

1035

No. of deaths

12 (0.046)

16 (0.031)

20 (0.030)

14 (0.016)

27 (0.030)

28 (0.042)

47 (0.045)

Model 1

(HR, 95% CI)

3.01 (1.39–6.50), P = 0.005

1.96 (0.96–4.03), P = 0.07

1.90 (0.96–3.77), P = 0.07

1.00

1.92 (1.01–3.66), P = 0.05

2.63 (1.39–5.00), P = 0.003

3.04 (1.67–5.51), P < 0.001

Model 2

(HR, 95% CI)

3.68 (1.68–8.05), P = 0.001

2.11 (1.02–4.34), P = 0.04

2.07 (1.04–4.11), P = 0.04

1.00

1.69 (0.89–3.24), P = 0.11

2.30 (1.20–4.39), P = 0.01

2.50 (1.37–4.57), P = 0.003

Born ≥ 1940^& cohort

1107

2151

2180

1889

1780

1043

1416

No. of deaths

2 (0.002)

12 (0.006)

8 (0.004)

11 (0.006)

12 (0.007)

9 (0.009)

4 (0.003)

Model 1

(HR, 95% CI)

0.33 (0.07–1.50), P = 0.15

0.97 (0.43–2.21), P = 0.95

0.65 (0.26–1.63), P = 0.36

1.00

1.17 (0.52–2.65), P = 0.71

1.49 (0.62–3.59), P = 0.38

0.48 (0.15–1.51), P = 0.21

Model 2

(HR, 95% CI)

0.37 (0.08–1.69), P = 0.20

1.14 (0.50–2.60), P = 0.76

0.70 (0.28–1.76), P = 0.45

1.00

1.14 (0.50–2.61), P = 0.75

1.35 (0.56–3.30), P = 0.51

0.42 (0.13–1.34), P = 0.14