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Table 4 Association between fatal stroke occurrence and reproductive years in the GBCS

From: Age at menarche, age at menopause, reproductive years and risk of fatal stroke occurrence among Chinese women: the Guangzhou Biobank Cohort Study

 

Duration of reproductive years

≤ 28

29–31

32–34

35–37

≥ 38

Total cohort

1511

2193

4025

5114

3661

No. of deaths

49 (0.032)

32 (0.015)

49 (0.012)

58 (0.011)

36 (0.010)

Model 1 (HR, 95% CI)

2.69 (1.81–4.00), P < 0.001

1.18 (0.76–1.85), P = 0.46

1.00

0.90 (0.61–1.33), P = 0.60

0.81 (0.52–1.24), P = 0.33

Model 2 (HR, 95% CI)

1.91 (1.28–2.86), P = 0.001

0.97 (0.62–1.52), P = 0.90

1.00

1.09 (0.74–1.61), P = 0.65

1.11 (0.72–1.72), P = 0.64

Born < 1940$ cohort

713

878

1283

1293

771

No. of deaths

41 (0.058)

29 (0.033)

38 (0.030)

33 (0.026)

23 (0.030)

Model 1 (HR, 95% CI)

2.03 (1.30–3.15), P = 0.002

1.13 (0.70–1.83), P = 0.62

1.00

0.86 (0.54–1.36), P = 0.51

1.00 (0.60–1.68), P = 0.99

Model 2 (HR, 95% CI)

1.79 (1.15–2.80), P = 0.01

1.05 (0.65–1.71), P = 0.83

1.00

0.89 (0.56–1.42), P = 0.62

1.14 (0.67–1.93), P = 0.62

Born ≥ 1940& cohort

798

1315

2742

3821

2890

No. of deaths

8 (0.010)

3 (0.002)

11 (0.004)

25 (0.006)

13 (0.004)

Model 1 (HR, 95% CI)

2.51 (1.01–6.25), P = 0.047

0.56 (0.16–2.01), P = 0.37

1.00

1.50 (0.73–3.07), P = 0.27

1.10 (0.50–2.47), P = 0.81

Model 2 (HR, 95% CI)

2.11 (0.84–5.27), P = 0.11

0.52 (0.14–1.86), P = 0.31

1.00

1.63 (0.79–3.36), P = 0.19

1.13 (0.51–2.55), P = 0.76

  1. $Postmenopausal women born before 1940 were analyzed; &Postmenopausal women born in 1940 or later were analyzed; model 1: a crude hazard ratio model without adjustments; model 2: a multivariate adjust model including age, diabetes, hypertension, dyslipidemia, smoking, alcohol drinking, physical activity, body mass index, self-rated health, education, job, family income, number of children and oral contraceptive pill use