The value of p16INK4a immunostaining for high-grade squamous intraepithelial lesions in human papillomavirus-negative patients

Table 6 Comparison of different methods for detecting cervical precancerous lesions

Parameter	Cytology	Colposcopy	p16^INK4a immunostaining (positive staining)	p16^INK4a immunostaining (positive and focal positive staining)
Sensitivity	52.4	38.5	92.3	100
Specificity	76.2	94.8	99.0	80.2
PPV	31.4	66.7	96.0	57.8
NPV	88.5	85.1	97.9	100
Kappa with H&E staining	0.327	0.323	0.926

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