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Table 5 Enzyme-labeled staining for ER, PR, HER-2 and Ki-67 across subgroups

From: Molecular phenotypes and clinical characterization of familial hereditary breast cancer among half and full sisters

Variable

NHBC

HBC

Total

CHBC

NCHBC

CHBC + NCHBC

Expression of ER, n

152

18

20

38

190

 (−)

44

2

2

4

48

 (+)

22

1

5

6

28

 (++)

15

7

1

8

23

 (+++)

71

8

12

20

91

Expression of PR, n

 (−)

53

2

0

2

55

 (+)

25

1

8

9

34

 (++)

28

5

7

12

40

 (+++)

46

10

5

15

61

Expression of HER-2, n

 (−)

66

2

6

8

74

 (±) (fish negative)

22

6

5

11

33

 (+) (fish positive)

16

2

3

5

21

 (++)

40

3

4

7

47

 (+++)

8

5

2

7

15

Expression of Ki-67, n

 (−)

36

6

7

13

49

 (+)

36

2

3

5

41

 (++)

60

6

8

14

74

 (+++)

20

4

12

6

26

Molecular phenotypes, n

 Luminal A

51

5

10

15

66

 Luminal B

10

3

1

4

14

 Her-2(+)

76

10

9

10

95

 Triple negative

15

0

0

0

15

  1. HBC hereditary breast cancer, NHBC non-hereditary breast cancer, CHBC contemporaneous hereditary breast cancer, NCHBC non-contemporaneous hereditary breast cancer
  2. ER/PR/HER-2, (−): less than 1% staining, (+): 1% ~ 30% staining, (++): 30% ~ 80% staining, (+++): more than 80% staining, for HER-2, (±)Fish negative, HER-2 gene non-amplification, (+) Fish positive, HER-2 gene amplification; for Ki-67: (−): less than 14% staining, (+): 15% ~ 25% staining, (++): 25% ~ 50% staining, (+++): more than 50% staining