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Table 2 Association of weighted PRS in different subgroups of endometriosis patients

From: Applicability of polygenic risk scores in endometriosis clinical presentation

   

Crude OR (95% CI)

p-value

Adj. OR

(95% CI)

p-value

Isolated/spread

Isolated/spread

p-value

    

Quartile 1

10/23

0.111

1.000

 

1.000

 

Quartile 2

15/18

 

0.522

(0.190–1.433)

0.207

0.496

(0.154–1.599)

0.240

Quartile 3

20/16

 

0.348

(0.129–0.938)

0.037

0.252

(0.081–0.782)

0.017

Quartile 4

11/23

 

0.909

(0.324–2.554)

0.857

0.616

(0.192–1.974)

0.415

P for trend

     

0.243

No GI tract involvement /GI tract involvement

No GI tract

involvement /GI tract involvement

P-value

    

Quartile 1

26/7

0.144

1.000

 

1.000

 

Quartile 2

30/3

 

0.371

(0.087–1.581)

0.181

0.158

(0.026–0.949)

0.044

Quartile 3

28/8

 

1.101

(0.349–3.470)

0.870

0.950

(0.248–3.644)

0.940

Quartile 4

23/11

 

1.1776

(0.591–5.343)

0.306

1.962

(0.524–7.338)

0.317

P for trend

     

0.100

No GI symptoms/

GI symptoms

No GI-symptoms/

GI-symptoms

P-value

    

Quartile 1

5/30

0.631

1.000

 

1.000

 

Quartile 2

3/29

 

1.611

(0.352–7.364)

0.538

4.219

(0.509–34.978)

0.182

Quartile 3

7/29

 

0.690

(0.197–2.425)

0.563

0.317

(0.065–1.539)

0.154

Quartile 4

7/28

 

0.667

(0.190–2.345)

0.528

0.530

(0.102–2.761)

0.451

P for trend

     

0.138

No hormone therapy /hormone therapy

No hormone therapy /hormone therapy

P-value

    

Quartile 1

18/17

0.902

1.000

 

1.000

 

Quartile 2

18/16

 

0.941

(0.366–2.421)

0.900

1.052

(0.344–3.213)

0.930

Quartile 3

20/16

 

0.847

(0.333–2.155)

0.727

0.713

(0.243–2.087)

0.537

Quartile 4

21/14

 

0.706

(0.274–1.820)

0.471

0.613

(0.205–1.830)

0.380

P for trend

     

0.285

  1. Adj = adjusted, CI = confidence, OR = odds ratio. PRS = polygenic risk scores. ORs and 95% CI were calculated using binary logistic regression model, adjusted for PC1, PC2, PC3 and PC4. The calculations with isolated/spread endometriosis, no GI-symptoms/GI-symptoms and no hormone/hormone therapy were also adjusted for age. The calculations with no GI-symptoms/GI-symptoms was also adjusted for hormone therapy. Fisher´s exact test was used to calculate the distribution of PRS quartiles among groups. P-values < 0.05 were considered statistically significant