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Table 3 Mortality from stroke, CHD, and RERI, according to education level and parity

From: Super-additive associations between parity and education level on mortality from cardiovascular disease and other causes: the Japan Collaborative Cohort Study

 

Education level

RERI(95%CI)

P value for RERI

Low

Low

High

High

Parity

Nulliparous

Parity ≥ 1

Nulliparous

Parity ≥ 1

Person-years

8686

246,667

16,318

400,450

  

Stroke

    

1.07 (− 0.30 to 2.44)

0.08

    No

28

492

24

359

  

    Age-adjusted HR (95%CI)

1.83 (1.25–2.70)

1.36 (1.19–1.56)

1.22 (0.80–1.84)

1.00

  

    Multivariable HR (95%CI)

1.67 (1.13–2.47)

1.33 (1.15–1.53)

1.24 (0.82–1.88)

1.00

  

    Age-adjusted mortality rate

2.94

2.47

2.41

1.72

  

Coronary heart disease

    

1.46 (− 0.81 to 3.73)

0.20

    No

15

204

10

157

  

    Age-adjusted HR (95%CI)

2.17 (1.28–3.69)

1.24 (1.01–1.54)

1.14 (0.60–2.15)

1.00

  

    Multivariable HR (95%CI)

1.98 (1.15–3.39)

1.20 (0.97–1.49)

1.16 (0.61–2.21)

1.00

  

    Age-adjusted mortality rate

1.64

1.19

0.83

0.76

  
  1. Multivariable adjustment: age, body mass index, history of hormonal drug use, habitual exercise or walking, current smoking, current drinking, sleep hours, history of hypertension, history of diabetes, perceived mental stress, and regular employment
  2. RERI > 0 indicates additive interaction of nulliparity and low education
  3. HR, hazard ratio; CI, confidence interval; CHD, coronary heart disease; RERI, the relative excess risk due to interaction
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