Table 3 Factors affecting the decision to pursue risk-reducing BSO among women diagnosed with a BRCA1/2 pathogenic variant and who were eligible for risk-reducing BSO in Nova Scotia, Canada between January 1, 2006 and December 31, 2016
Factor | Pursued risk-reducing BSO (n = 85) n (%) | Did not pursue risk-reducing BSO (n = 47) n (%) | p-value |
|---|---|---|---|
Age at time of genetic diagnosis, mean (SD) | 46.8 (9.1) | 39 (17) | < 0.001* |
Personal history of breast cancer | 46 (54) | 12 (26) | 0.002* |
Personal history of ovarian cancer | 1 (1) | 0 (0) | 1.00 |
Risk-reducing bilateral mastectomy | 13 (15) | 3 (6) | 0.17 |
Family history of breast cancer | 81 (95) | 42 (89) | 0.20 |
Family history of ovarian cancer | 36 (42) | 25 (53) | 0.23 |
Previous use of OCP | 27 (32) | 26 (55) | 0.008* |
No prior use OCP | 10 (12) | 10 (21) | 0.14 |