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Table 3 Prognostic factors of breast cancer DFS using cox mixture cure model

From: Long-term outcomes of non-metastatic breast cancer patients by molecular subtypes

Variable

Univariate

Multivariate

HR (95% CI)

P-value

OR (95% CI)

P-value

HR (95% CI)

P-value

OR (95% CI)

P-value

Age

 < 50

Ref

 

Ref

 

Ref

 

Ref

 

 ≥ 50

1.27 (1,1.61)

0.049

0.78 (0.62,0.99)

0.037

0.8 (0.53,1.22)

0.302

0.81 (0.53,1.23)

0.319

BMI

 < 30

Ref

 

Ref

 

Ref

 

Ref

 

 ≥ 30

1.08 (0.85,1.38)

0.512

0.45 (0.36,0.58)

 < 0.001

0.94 (0.72,1.23)

0.654

0.41 (0.3,0.56)

 < 0.001

Marital status

        

Single

Ref

 

Ref

 

Ref

 

Ref

 

Married

0.87 (0.69,1.1)

0.242

1.56 (1.18,2.07)

0.002

1.28 (0.93,1.76)

0.131

1.62 (1.14,2.3)

0.007

Education level

 < diploma

Ref

 

Ref

 

Ref

 

Ref

 

 ≥ diploma

1.27 (0.95,1.71)

0.106

1.82 (1.46,2.28)

 < 0.001

0.7 (0.53,0.91)

0.009

1.13 (0.85,1.49)

0.390

Family history

No

Ref

 

Ref

 

Ref

 

Ref

 

Yes

0.58 (0.41,0.82)

0.002

0.48 (0.34,0.66)

 < 0.001

0.94 (0.64,1.37)

0.747

0.66 (0.45,0.99)

0.042

Menopausal status

Premenopausal

Ref

 

Ref

 

Ref

 

Ref

 

Postmenopausal

1.35 (1.07,1.72)

0.013

0.79 (0.62,0.99)

0.042

1 (0.66,1.53)

0.998

0.63 (0.41,0.96)

0.031

Pathology

        

Others

Ref

 

Ref

 

Ref

 

Ref

 

Inv. Ductal Ca

0.89 (0.59,1.34)

0.565

0.56 (0.39,0.82)

0.003

0.68 (0.4,1.15)

0.145

0.26 (0.15,0.44)

 < 0.001

Tumor size (cm)

 < 2

Ref

 

Ref

 

Ref

 

Ref

 

2–5

1.97 (1.41,2.76)

 < 0.001

0.99 (0.75,1.31)

0.968

1.39 (0.85,2.28)

0.195

1.13 (0.68,1.88)

0.644

 > 5

3.2 (2.22,4.62)

 < 0.001

0.67 (0.48,0.93)

0.015

1.99 (1.1,3.6)

0.023

1.86 (0.96,3.57)

0.064

Tumor grade

1

Ref

 

Ref

 

Ref

 

Ref

 

2

0.8 (0.56,1.14)

0.214

0.63 (0.44,0.92)

0.015

1.04 (0.7,1.55)

0.855

1.15 (0.75,1.75)

0.521

3

1.51 (1.03,2.23)

0.036

0.59 (0.39,0.88)

0.010

1.35 (0.86,2.12)

0.190

0.93 (0.57,1.52)

0.776

Stage

I

Ref

 

Ref

 

Ref

 

Ref

 

II

1.94 (1.29,2.93)

0.002

1.13 (0.81,1.58)

0.460

1.04 (0.52,2.05)

0.921

1.3 (0.67,2.51)

0.433

III

2.22 (1.47,3.35)

 < 0.001

0.45 (0.32,0.65)

 < 0.001

0.49 (0.22,1.12)

0.091

0.21 (0.09,0.48)

 < 0.001

LN metastasis

No

Ref

 

Ref

 

Ref

 

Ref

 

Yes

1.5 (1.15,1.96)

0.003

0.53 (0.41,0.67)

 < 0.001

1.58 (1.04,2.39)

0.031

1.15 (0.76,1.74)

0.510

Molecular subtype

HR+/Her2−

Ref

 

Ref

 

Ref

 

Ref

 

HR+/Her2+

1.53 (1.11,2.12)

0.010

1.17 (0.87,1.58)

0.295

1.34 (0.95,1.89)

0.098

1.27 (0.9,1.8)

0.177

HR−/Her2+

1.38 (1.01,1.89)

0.045

0.38 (0.27,0.55)

 < 0.001

0.91 (0.6,1.39)

0.654

0.22 (0.13,0.38)

 < 0.001

HR−/Her2−

1.78 (1.26,2.5)

0.001

1.28 (0.92,1.78)

0.139

1.5 (0.94,2.39)

0.091

1.08 (0.65,1.81)

0.767

Type of surgery

MRM

Ref

 

Ref

 

Ref

 

Ref

 

BCS

0.57 (0.45,0.73)

 < 0.001

1.51 (1.21,1.89)

 < 0.001

0.55 (0.41,0.75)

 < 0.001

0.97 (0.71,1.35)

0.876

Hormone therapy

No

Ref

 

Ref

 

Ref

 

Ref

 

Yes

0.67 (0.51,0.9)

0.007

1.34 (0.99,1.81)

0.059

1.04 (0.7,1.56)

0.848

0.98 (0.59,1.62)

0.931

Radiotherapy

No

Ref

 

Ref

 

Ref

 

Ref

 

Yes

1.15 (0.79,1.67)

0.479

0.89 (0.61,1.3)

0.553

1.1 (0.68,1.79)

0.699

0.92 (0.54,1.56)

0.761

Adjuvant chemotherapy

No

Ref

 

Ref

 

Ref

 

Ref

 

Yes

0.61 (0.44,0.83)

0.002

1.1 (0.83,1.45)

0.499

0.55 (0.39,0.78)

0.001

0.76 (0.53,1.1)

0.144

  1. HR hazard ratio, OR odds ratio, CI confidence interval, MRM modified radical mastectomy, BCS breast-conserving surgery
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