Table 1 Summary of the cervical cancer study characteristics

Hodel [36]

1982

Retrospective

Stage 1B cervical cancer

7

Open

NR

0

1

6

5

1

0

Husseinzadeh [17] 1984

Prospective

15/22 from surgery only group were included for which FSH levels were available

19

Open

NR

15

0

4

17

0

0

Ploch [18]

1988

Prospective

Focus on ovarian function only, additional analysis of location of transposed ovaries

22

Lap

13 (2–23)

5

5

12

15

0

0

Owens [19]

1989

Retrospective

All but three patients had early-stage cervical cancer, one patient had unilateral OT

14

Open

18

6

0

8

13

0

0

Chambers [21]

1990

Retrospective

Stage 1 cervical cancer,

description of lateral OT

25

Open (sc)

14 (2–23)

25

0

0

22

6

0

Van Beurden [39] 1990

Retrospective

FSH levels were available for 6 patients

6

Open

23 (10–36)

0

0

6

1

0

0

Chambers [21]

1991

Retrospective

Stage 1 cervical cancer, ovarian preservation causally related to estimated scattered dose to ovaries

38

Open

35

24

0

14

27

7

0

Anderson [22]

1993

Retrospective

Comparison with a non- transposition group

82

Open / Lap

44

58

0

24

51

38

1

Bidzinski [23]

1993

Prospective

Stage 1 cervical cancer, ultrasound examination showed distinct reduction of transposed ovary echo structure in 91% cases

48

Open

41 (10–72)

9

24

15

45

0

0

Feeney [24]

1995

Retrospective

Ovarian function is reserved only in 50% of patients with postoperative BR

132

Lap

24

104

0

28

115

4

2

Clough [6]

1996

Prospective

Unilateral OT, success rate 100% in patients younger than 40 years old

17

Open

23.6 (12–33)

0

11

6

15

0

0

Covens [37]

1996

Retrospective

Patients with 1B cervical cancer prior to RT

3

Open

32

0

0

3

2

0

0

Fujiwara [25]

1997

Retrospective

Description of a new technique for OT

27

Open (sc)

27 (10–44)

25

1

1

26

18

0

Morice

1998

Prospective

Only 14/ 24 were included as they were repeated in other paper published by the same author

14

Lap

6

0

10

4

11

0

0

Morice [26]

2000

Prospective

95/107 patients were included; 12 patients were lost on follow up

95

Lap

31 (10–56)

11

59

25

79

25

1

Buekers [27]

2001

Retrospective

Stage 1 cervical cancer, 27 women had unilateral oophorectomy for intraoperative suspicion or vascular compromise

80

Open

87 (43–126)

54

0

26

64

0

0

Olejek [28]

2001

Prospective

Significance in ovarian preservation between RT and non-RT groups

44

Open

60

19

6

19

31

3

0

Yamamoto [11]

2001

Prospective

Regression analysis of risk factors for ovarian metastases

56

Open

12

30

0

26

50

0

0

Nagao [29]

2006

Retrospective

Subcutaneous fat OT, direct comparison to a non-transposition group

27

Open (sc)

65

22

0

5

25

3

0

Pahisa [30]

2008

Prospective

24/28 patients with 1b1 cervical cancer were included for which follow up was available

24

Open / Lap

44

13

6

5

20

2

0

Al-Badawi [31]

2010

Retrospective

Stage 1–2 cervical cancer, 11/14 women were < 40 years old

15

Lap

33

0

0

15

11

0

0

Han [38]

2011

Retrospective

19/29 patients with cervical cancer for which FSH was available

19

Open / Lap

17.2

0

0

19

11

3

0

Hwang [32]

2012

Retrospective

39/53 patients were included; 14 patients were lost on follow up or FSH not available

39

Open / Lap

39.8

8

0

31

18

1

0

Zhao [43] 2013

Retrospective

Stage 1–2 cervical cancer, risk factors for ovarian metastases reported

105

Open

N/R

105

0

0

-

-

2

Shou [40]

2015

Retrospective

6/26 patients with IIB-IIIB cervical cancer for which follow-up was available

26

Lap

N/R

0

0

26

18

-

0

Du Z [33]

2017

Retrospective

52/86 patients had concurrent chemotherapy; the relationship between ovarian function and ovarian limited dose (IMRT) in radiotherapy was evaluated

86

Open

6

21

0

13

34

-

-

Swift [34]

2018

Retrospective

9 patients with stage 1B1-2A cervical cancer, those who had chemoradiotherapy were excluded, description of a novel technique of laparoscopic lateral OT

6

lap

8–103

2

0

4

6

1

0

Hoeckman [35] 2018

Retrospective

23 patients with cervical carcinoma

23

Open/lap

34.5 (1.5–96)

0

0

23

16

0

0

Lv [41]

2019

Retrospective

77/150 patients,45 years who had complete follow-up, the association between the location of the transposed ovary and the ovarian dose was examined

77

Open

12

0

0

77

56

0

0

Yin L [42] 2019

Retrospective

105/118 patients received limited dose IMRT

118

Open

12

0

0

118

41

-

0

Total

1160

2–126

449

132

579

819

125

4