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Table 3 Genotype and allele frequencies of the IL-1β (+ 3954) polymorphism between women with and without endometriosis

From: Polymorphisms of TNF-alpha (− 308), IL-1beta (+ 3954) and IL1-Ra (VNTR) are associated to severe stage of endometriosis in Mexican women: a case control study

IL-1β

n

Genotype n (%)

Allele n (%)

*1*1

*1*2

*2*2

*1*2 + *2*2

1

2

Women without endometriosis

186

135 (72.6)

46 (24.7)

5 (2.7)

51(27.4)

316 (84.9)

56 (15.1)

Women with endometriosis

183

129 (70.5)

47 (25.7)

7 (3.8)

54 (29.5)

305 (83.3)

61 (16.7)

Stage I

63

51 (80.9)

9 (14.3)

3 (4.8)

12 (19.0)

111 (88.1)

15 (11.9)

Stage II

54

36 (66.7)

16 (29.6)

2 (3.7)

18 (33.3)

88 (81.5)

20 (18.5)

Stage I/II

117

87 (74.4)

25 (21.4)

5 (4.3)

30 (25.6)

199 (85.0)

35 (15.0)

Stage III

42

30 (71.4)

11 (26.2)

1 (2.4)

12 (28.6)

71 (84.5)

13 (15.5)

Stage IV

24

12 (50.0)

11 (45.8)1

1 (4.2)

12 (50.0)2

35 (72.9)

13 (27.1)

Stage III/IV

66

42 (63.6)

22 (33.3)

2 (3.0)

24 (36.4)

106 (80.3)

26 (19.7)

  1. 1x2 = 4.03, p = 0.044, OR = 2.69 (95% CI 1.11–6.51) versus women without endometriosis
  2. 2x2 = 4.14, p = 0.041, OR = 2.64 (95% CI 1.11–6.27) versus women without endometriosis