Evaluation of the food effect on a drospirenone only contraceptive containing 4 mg administered with and without high-fat breakfast in a randomised trial

Table 3 90% confidence intervals of drospirenone

Drospirenone (n = 24)
Variable	Method	Point estimator	Confidence intervals	CV(%)
AUC(0-72 h) (Ratio TEST ‘A’ with food vs. TEST ‘B’ without food)	ANOVA-log	107.99%	104.72%–111.36%	6.21%
Cmax (Ratio TEST ‘A’ with food vs. TEST ‘B’ without food)	ANOVA-log	129.35%	118.58%–141.10%	17.68%

CV coefficient of variation. AUC(0–72) Area under the concentration/time curve from time 0 h to the last observed concentration at 72 h. Tmax timepoint of maximal concentration; Cmax observed maximal concentration after administration

ISSN: 1472-6874