Table 1 Key information about the weight loss studies included in analyses
Study | Year of baseline weight | Age at self-reported young adult weight (y) | Key inclusion criteria | Ethics committee and registration number | Funding information | Trial registry details | |||
|---|---|---|---|---|---|---|---|---|---|
Breast cancer risk | Current weight | Adult weight gain | Menopausal status | ||||||
Lifestyle | 2002 | 20 | Risk 1 in 8 to 1 in 3 | BMI < 40 kg/m2 | Weight gain > 10 kg since age 18 | Premenopausal | South Manchester REC (01/426) | Prevent Breast Cancer (registered charity number 1109839) | NIHR NRR N0226132725 |
IER vs CER diets | 2009–10 | 18 | Risk 1 in 6 to 1 in 3 | BMI 24–45 kg/ m2 and / or body fat > 30%. | Weight gain > 7 kg since age 20 | Any | Bolton (Lancashire) Local REC (05/Q1409/42) | Prevent Breast Cancer (as above) and Breast Cancer Now (registered charity number 1160558) | ISRCTN52913838 |
BRRIDE | 2009–10 | 18 | Risk ≥1 in 6 | BMI 24–35 kg/ m2 | Not defined | Premenopausal | North West 10 REC, Greater Manchester North (09/H1006/33) | Prevent Breast Cancer (as above) | ISRCTN77916487 |
PROCAS-Lifestyle | 2014–16 | 18 | Not defined | BMI ≥25 kg/m2 | Not defined | Any | NRES Committee West Midlands–Solihull (14/WM/1088) | Prevent Breast Cancer (as above) | ISRCTN91372184 |
BRRIDE 2 | 2015 | 18 | Not defined | BMI 30–45 kg/m2 plus body fat ≥40% or waist ≥88 cm. Weight < 125 kg | Not defined | Premenopausal | NRES Committee South Central - Oxford B (14/SC/1097) | Prevent Breast Cancer (as above) | ISRCTN10803394 |
Family History Lifestyle | 2017–19 | 18 | Moderately increased / high risk (> 17% lifetime risk) | BMI ≥25 kg/m2 | Not defined | Any | North West - Preston Research Ethics Committee (17/NW/0440) | Prevent Breast Cancer (as above) | ISRCTN16431108 |