IVF | ICSI | P-value | |
---|---|---|---|
No. of patients | 3806 | 371 | |
Years of treatment, n (%) | < 0.01 | ||
2017 | 863 (87.17) | 127 (12.83) | |
2018 | 988 (90.98) | 98 (9.02) | |
2019 | 1071 (92.01) | 93 (7.99) | |
2020 | 884 (94.34) | 53 (5.66) | |
Female age (years) | 31.74 ± 3.82 | 32.22 ± 4.27 | 0.02 |
< 30, n (%) | 1096 (28.80) | 101 (27.22) | < 0.01 |
30–34 | 1873 (49.21) | 159 (42.86) | |
35–37 | 535 (14.06) | 61 (16.44) | |
38–40 | 219 (5.75) | 37 (9.97) | |
41–43 | 83 (2.18) | 13 (3.50) | |
Male age (years) | 33.44 ± 4.49 | 34.58 ± 5.22 | < 0.01 |
Body mass index (kg/m2) | 23.36 ± 3.68 | 23.60 ± 3.49 | 0.22 |
< 18.5, n (%) | 236 (6.20) | 12 (3.23) | 0.22 |
18.5–24.9 | 2463 (64.71) | 246 (66.31) | |
25–29.9 | 888 (23.33) | 96 (25.88) | |
30–34.9 | 187 (4.91) | 14 (3.77) | |
≥ 35 | 23 (0.60) | 2 (0.54) | |
Missing | 9 (0.24) | 1 (0.27) | |
Education level, n (%) | 0.63 | ||
Primary | 183 (4.81) | 22 (5.93) | |
High school | 2820 (74.09) | 272 (73.32) | |
College | 803 (21.10) | 77 (20.75) | |
Smoker n (%) a | 862 (22.65) | 67 (18.06) | 0.04 |
Gravidity, n (%) | |||
0 | 2147 (56.41) | 231 (62.26) | 0.07 |
1 | 920 (24.17) | 83 (22.37) | |
≥ 2 | 739 (19.42) | 57 (15.36) | |
No. of prior live births, n (%) | 0.02 | ||
0 | 3081 (80.95) | 322 (86.79) | |
1 | 660 (17.34) | 44 (11.86) | |
≥ 2 | 65 (1.71) | 5 (1.35) | |
AFC, n | 13.21 ± 6.49 | 12.87 ± 6.39 | 0.35 |
Infertility durationb, years | 6 (5–7) | 6 (5–8) | < 0.01 |
Causing of infertility, n (%) | < 0.01 | ||
Tubal factor | 2164 (56.86) | 218 (58.76) | |
Ovulatory disorder | 861 (22.62) | 80 (21.56) | |
Diminished ovarian reserve | 142 (3.73) | 24 (6.47) | |
Endometriosis | 148 (3.89) | 11 (2.96) | |
Unexplained | 463 (12.17) | 22 (5.93) | |
Others | 28 (0.74) | 16 (4.31) | |
Ovarian stimulation protocol, n (%) | 0.87 | ||
Depot GnRH agonist | 1534 (40.30) | 144 (38.81) | |
GnRH agonist | 1032 (27.12) | 103 (27.76) | |
GnRH antagonist | 1131 (29.72) | 111 (29.92) | |
Micro stimulation | 109 (2.86) | 13 (3.50) | |
No. of oocytes retrieved | 10.35 ± 5.99 | 10.46 ± 6.18 | 0.73 |
1–5, n (%) | 845 (22.20) | 75 (20.22) | |
6–9 | 1049 (27.56) | 113 (30.46) | |
10–15 | 1239 (32.55) | 121 (32.61) | |
≥ 16 | 673 (17.68) | 62 (16.71) | |
No. MII oocytes | 9.66 ± 5.67 | 8.78 ± 5.40 | < 0.01 |
No. 2PN | 6.53 ± 4.25 | 6.25 ± 4.33 | 0.22 |
Fertilization rate (% per MII) | 67.64 | 71.15 | < 0.01 |
Total fertilization failure, n (%) | 70 (1.84) | 10 (2.70) | 0.25 |
Cycles with no embryo viable, c n (%) | 184 (4.83) | 15 (4.04) | 0.50 |
No. of embryos available | 5.51 ± 3.93 | 5.06 ± 3.83 | 0.03 |
Blastulation rate (%) | 63.79 | 52.70 | < 0.01 |
No. of embryos cryopreserved | 3.07 ± 2.92 | 2.41 ± 2.45 | < 0.01 |