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Table 1 Demographics and cycle characteristics of patients with infertility ≥ 5 years

From: Duration of infertility and assisted reproductive outcomes in non-male factor infertility: can use of ICSI turn the tide?

 

IVF

ICSI

P-value

No. of patients

3806

371

 

Years of treatment, n (%)

  

 < 0.01

  2017

863 (87.17)

127 (12.83)

 

  2018

988 (90.98)

98 (9.02)

 

  2019

1071 (92.01)

93 (7.99)

 

  2020

884 (94.34)

53 (5.66)

 

Female age (years)

31.74 ± 3.82

32.22 ± 4.27

0.02

  < 30, n (%)

1096 (28.80)

101 (27.22)

 < 0.01

  30–34

1873 (49.21)

159 (42.86)

 

  35–37

535 (14.06)

61 (16.44)

 

  38–40

219 (5.75)

37 (9.97)

 

  41–43

83 (2.18)

13 (3.50)

 

Male age (years)

33.44 ± 4.49

34.58 ± 5.22

 < 0.01

Body mass index (kg/m2)

23.36 ± 3.68

23.60 ± 3.49

0.22

  < 18.5, n (%)

236 (6.20)

12 (3.23)

0.22

  18.5–24.9

2463 (64.71)

246 (66.31)

 

  25–29.9

888 (23.33)

96 (25.88)

 

  30–34.9

187 (4.91)

14 (3.77)

 

   ≥ 35

23 (0.60)

2 (0.54)

 

  Missing

9 (0.24)

1 (0.27)

 

Education level, n (%)

  

0.63

  Primary

183 (4.81)

22 (5.93)

 

  High school

2820 (74.09)

272 (73.32)

 

  College

803 (21.10)

77 (20.75)

 

Smoker n (%) a

862 (22.65)

67 (18.06)

0.04

Gravidity, n (%)

  0

2147 (56.41)

231 (62.26)

0.07

  1

920 (24.17)

83 (22.37)

 

  ≥ 2

739 (19.42)

57 (15.36)

 

No. of prior live births, n (%)

  

0.02

  0

3081 (80.95)

322 (86.79)

 

  1

660 (17.34)

44 (11.86)

 

  ≥ 2

65 (1.71)

5 (1.35)

 

AFC, n

13.21 ± 6.49

12.87 ± 6.39

0.35

Infertility durationb, years

6 (5–7)

6 (5–8)

 < 0.01

Causing of infertility, n (%)

  

 < 0.01

  Tubal factor

2164 (56.86)

218 (58.76)

 

  Ovulatory disorder

861 (22.62)

80 (21.56)

 

  Diminished ovarian reserve

142 (3.73)

24 (6.47)

 

  Endometriosis

148 (3.89)

11 (2.96)

 

  Unexplained

463 (12.17)

22 (5.93)

 

Others

28 (0.74)

16 (4.31)

 

Ovarian stimulation protocol, n (%)

  

0.87

  Depot GnRH agonist

1534 (40.30)

144 (38.81)

 

  GnRH agonist

1032 (27.12)

103 (27.76)

 

  GnRH antagonist

1131 (29.72)

111 (29.92)

 

  Micro stimulation

109 (2.86)

13 (3.50)

 

No. of oocytes retrieved

10.35 ± 5.99

10.46 ± 6.18

0.73

  1–5, n (%)

845 (22.20)

75 (20.22)

 

  6–9

1049 (27.56)

113 (30.46)

 

  10–15

1239 (32.55)

121 (32.61)

 

  ≥ 16

673 (17.68)

62 (16.71)

 

No. MII oocytes

9.66 ± 5.67

8.78 ± 5.40

 < 0.01

No. 2PN

6.53 ± 4.25

6.25 ± 4.33

0.22

Fertilization rate (% per MII)

67.64

71.15

 < 0.01

Total fertilization failure, n (%)

70 (1.84)

10 (2.70)

0.25

Cycles with no embryo viable, c n (%)

184 (4.83)

15 (4.04)

0.50

No. of embryos available

5.51 ± 3.93

5.06 ± 3.83

0.03

Blastulation rate (%)

63.79

52.70

 < 0.01

No. of embryos cryopreserved

3.07 ± 2.92

2.41 ± 2.45

 < 0.01

  1. Data are expressed as mean ± SD or n (%). aIncluding the passive smoking status; bMedian (Interquartile range); cIncluding fertilization failures and arrested embryo development
  2. AFC Antral follicle counts, MII MetaphaseII, 2PN Two pronuclear