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Table 4 Biochemical and hormonal parameters were obtained for the Reproductive, Premenopausal and Postmenopausal groups

From: The correlation of the fecal microbiome with the biochemical profile during menopause: a Brazilian cohort study

Groups: Median (1º—3º Quartile) or M ± SD

p-value

Biochemical and Hormonals

Reproductive (a)

Premenopausal (b)

Postmenopausal (c)

a-b

a-c

b-c

Glucose mg/dl

86.5 (81—93.7)

92.5 (85—112.8)

94.5 (82.7—103)

0.2332

0.1223

 > 0.9999

Cholesterol mg/dl

195.0 ± 28.2

204.0 ± 51.1

228.9 ± 51.4

0.8141

0.0280*

0.0782

Triglycerides mg/dl

74.0 (53—88)

130.5 (100—160)

117.0 (93 -190)

0.0006***

0.0002***

 > 0.9999

HDL mg/dl

62.5 (47.7—69.2)

48.0 (43.7—58.5)

54.0 (43.7—66.5)

0.1534

 > 0.9999

0.3116

LDL mg/dl

120.8 ± 30.7

125.3 ± 41.8

143.2 ± 44.8

0.9352

0.1232

0.1725

VLDL mg/dl

15.0 (10.7—17.5)

26.0 (20—32.2)

23.0 (19—38)

0.0007**

0.0002***

 > 0.9999

Lipoprotein A mg/dl

21.7 (11.2—33.6)

12.5 (4.4—45.3)

22.7 (10.2—55.6)

 > 0.9999

 > 0.9999

0.7908

ApoA

167.3 ± 32.6

165.5 ± 20.3

177.7 ± 34.5

0.9818

0.4409

0.2339

ApoB

93.0 (84—125.3)

117.1 (95 -131.3)

127.5 (98—152.8)

0.5096

0.0195*

0.5521

Urea mg/dl

23.5 (16—31)

26.5 (25—35)

30.5 (25.7—36.2)

0.2418

0.0061**

0.6262

Creatinin mg/dl

0.72 (0.67—0.78)

0.72 (0.65—0.82)

0.75 (0.68—0.86)

 > 0.9999

0.7903

0.5458

Calcium mg/dL

9.37 ± 0,26

9.63 ± 0,39

9.83 ± 0,38

0.0579

 < 0.0001****

0.0558

Phosphorus mg/dl

3.44 ± 0,38

3.68 ± 0,48

3.70 ± 0,46

0.2157

0.0922

0.9722

Uric acid mg/dl

4.25 (3.4—4.9)

4.8 (4.2—5.6)

5.1 (4.4—5.9)

0.0698

0.0102*

 > 0.9999

Reactive C protein

1.51 (0.65—3.3)

3.16 (1.3—6.9)

3.08 (1.6—4.7)

0.2091

0.1443

 > 0.9999

Alkaline phosphatase U/l

65.5 (52—80)

80.5 (66—95)

87.0 (73.2—105.5)

0.0872

0.0008***

0.5501

Vitamin D ng/ml

24.0 ± 7.0

22.7 ± 7.1

23.5 ± 6.3

0.8010

0.9494

0.8835

TSH mUI/dl

1.8 (1.7—2.4)

1.7 (1.1—2.9)

2.2 (1.4—3.3)

 > 0.9999

 > 0.9999

0.8978

Testosterone ng/dl

34.4 (19.8—45.4)

34.2 (21.6—48.3)

27.2 (18.5—39.3)

 > 0.9999

 > 0.9999

0.2275

Insulin µUI/ml

6.4 (4.4—8.3)

7.4 (4.4—11.1)

6.7 (4.5—10.3)

0.7279

 > 0.9999

 > 0.9999

Cortisol µg/dl

13.2 (9.6—19.4)

17.4 (9.4—25.1)

15.0 (9.6—21.4)

0.8025

 > 0.9999

 > 0.9999

SHBG µg/dl

57.5 ± 18.3

45.8 ± 17.2

37.1 ± 14.7

0.0236*

 < 0.0001****

0.0396*

SDHEA µg/dl

74.7 (47—111.8)

73.5 (49 – 102.8)

58.8 (37.8—84.2)

 > 0.9999

0.5580

0.0902

  1. Data are expressed as the mean ± standard deviation (M ± SD). Data was tested using One Way ANOVA Test with post-test Tukey's multiple comparisons. Non-parametric data are expressed as median (1º and 3º Quartile) and the Kruskal–Wallis test was used. p < 0.05 was considered statistically significant. Reproductive n = 18; Premenopause n = 26; Postmenopause n = 58
  2. HDL High-density lipoprotein, LDL Low-density lipoprotein, VLDL Very-low-density lipoprotein, ApoA Apoprotein A, ApoB Apoprotein B, TSH Thyrostimulating Hormone, SHBG Sex hormone-binding globulin, SDHEA dehydroepiandrosterone
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