Variables | OSa | CSSa | OS: SPMb | CSS: SPMb | ||||
---|---|---|---|---|---|---|---|---|
HR (95% CI) | p | HR (95% CI) | p | HR (95% CI) | p | HR (95% CI) | p | |
Age at BC diagnosis (years) | ||||||||
≥ 56 versus < 56 | 1.68 (1.06–2.67) | 0.027 | 1.64 (1.03–2.60) | 0.038 | 2.00 (1.26–3.16) | 0.003 | 1.95 (1.22–3.10) | 0.005 |
Age at SPM diagnosis (years) | ||||||||
 ≥ 62 versus < 62 | 1.43 (0.90–2.27) | 0.126 | 1.40 (0.88–2.22) | 0.156 | 2.15 (1.35–3.42) | 0.001 | 2.10 (1.32–3.35) | 0.002 |
TNM stage of BC | ||||||||
I + II (ref) |  |  |  |  |  |  |  |  |
III + IV | 1.29 (0.58–2.85) | 0.530 | 1.32 (0.60–2.92) | 0.498 | 1.57 (0.71–3.47) | 0.261 | 1.61 (0.73–3.55) | 0.241 |
Unclassified | 1.05 (0.60–1.84) | 0.869 | 1.07 (0.61–1.88) | 0.816 | 1.24 (0.71–2.19) | 0.445 | 1.27 (0.72–2.24) | 0.404 |
TNM stage of SPM | ||||||||
I + II (ref) |  |  |  |  |  |  |  |  |
III + IV | 5.08 (2.38–10.84) |  < 0.001 | 5.07 (2.38–10.83) |  < 0.001 | 7.13 (3.33–15.28) |  < 0.001 | 7.17 (3.34–15.36) |  < 0.001 |
Unclassified | 5.03 (2.44–10.40) |  < 0.001 | 4.90 (2.37–10.14) |  < 0.001 | 5.65 (2.72–11.74) |  < 0.001 | 5.53 (2.66–11.50) |  < 0.001 |
BC therapeutic hospital grade | ||||||||
Secondary versus tertiary | 0.82 (0.50–1.33) | 0.412 | 0.78 (0.48–1.28) | 0.328 | 0.72 (0.44–1.18) | 0.195 | 0.69 (0.42–1.14) | 0.146 |
SPM therapeutic hospital grade | ||||||||
Secondary versus tertiary | 1.40 (0.86–2.29) | 0.181 | 1.34 (0.81–2.21) | 0.251 | 1.78 (1.08–2.93) | 0.024 | 1.70 (1.02–2.83) | 0.040 |
Surgery for BC | ||||||||
No (ref) | Â | Â | Â | Â | Â | Â | Â | Â |
Yes | 1.24 (0.74–2.10) | 0.419 | 1.29 (0.76–2.20) | 0.340 | 1.02 (0.61–1.73) | 0.929 | 1.07 (0.63–1.82) | 0.806 |
Unknown | 0.68 (0.34–1.37) | 0.280 | 0.71 (0.35–1.43) | 0.337 | 1.64 (0.87–3.09) | 0.127 | 1.71 (0.90–3.24) | 0.100 |
Surgery for SPM | ||||||||
Yes versus No | 0.40 (0.25–0.65) |  < 0.001 | 0.41 (0.25–0.66) |  < 0.001 | 0.36 (0.22–0.57) |  < 0.001 | 0.36 (0.22–0.59) |  < 0.001 |
SPM sites | ||||||||
Colon and rectum | ||||||||
  No versus yes | 1.77 (0.91–3.45) | 0.094 | 1.74 (0.89–3.40) | 0.104 | 1.52 (0.80–2.88) | 0.202 | 1.50 (0.79–2.84) | 0.219 |
Thyroid | ||||||||
  No versus yes | 11.92 (1.66–85.84) | 0.014 | 11.77 (1.63–84.80) | 0.014 | 20.65 (2.87–148.69) | 0.003 | 20.44 (2.84–147.20) | 0.003 |
Lung and bronchus | ||||||||
  No versus yes | 0.90 (0.49–1.64) | 0.723 | 0.88 (0.48–1.61) | 0.686 | 0.70 (0.38–1.27) | 0.239 | 0.68 (0.38–1.25) | 0.216 |
Latency (years) | ||||||||
 > 5 versus ≤ 5 | 0.002 (0–0.07) | 0.001 | 0.002 (0–0.07) | 0.001 | 1.89 (1.17–3.05) | 0.009 | 1.85 (1.14–3.00) | 0.012 |
Latency × Timec | 1.08 (1.03–1.13) | 0.001 | 1.08 (1.03–1.12) | 0.001 | – | – | – | – |