Table 2 Morphophenotypic features summaries in differential diagnoses of the ovary adenomatoid tumors
From: Adenomatoid tumors of ovary mimicking malignancy: report of 2 cases and literature review
Similar neoplasms | Morphological features | IHC markers | Histochemical stain | Molecular pathology |
|---|---|---|---|---|
Adenomatoid tumors | Various growth patterns, signet ring and vacuolated cells with mild to moderate atypia | CK, CR, CK5/6, WT-1, D2-40, L1CAM, BAP1+; Ber-EP4, MOC31, ER, PR − | AB+; PAS−/weak+ | Lack BAP1 mutation and CDKN2A/p16 delection |
Krukenburg tumors | Signet ring cells and various other architectural patterns with a variably conspicuous stromal component | CK, EMA+ | Mucin+ | NS |
Well-differentiated papillary mesothelial tumors | Common patterns: papillary, tubulopapillary, adenomatoid-like and branching cords, cells with rare mitoses | CK, CR, CK5/6, WT-1, D2-40, L1CAM, BAP1+; EMA+/−; Ber-EP4,MOC31,ER,PR − | NS | Lack BAP1 mutation and CDKN2A/p16 delection |
Mesotheliomas | Common patterns: tubular, papillary and solid, cells with mild to moderate nuclear atypia and variable mitotic activity | CK, CK7, CR, CK5/6, WT-1, D2-40+; EMA+/−; L1CAM, BAP1, Ber-EP4, MOC31, ER, PR− | NS | Harbor BAP1 mutation and CDKN2A/p16 delection |
Yolk sac tumors | Multiple patterns: reticular/microcystic pattern most commonly and endodermal sinus pattern (Schiller-Duval bodies) most specific, cells with variable atyia | CK, SALL4, AFP, Glypican-3+; EMA, ER, PR, CD117, OCT4− | NS | NS |
Signet-ring stromal tumors | Signet ring cells with rare mitotic count present in fibroma stromal background | CK focal+; CR, CyclinD1, β-catenin(nuclear), CD10, SF1, SMA+; EMA, inhibin-α− | PAS −; Mucin − | NS |
Microcystic stromal tumors | A classic triad of microcysts, solid cellular zones, and fibrous stroma, cells with low mitotic activity | CK focal+; WT-1, CyclinD1, β-catenin (nuclear and cytoplasmic), CD10, SF1, FOXL-2 +; EMA, CR, inhibin-α, ER, PR −; AR+/− | NS | NS |
Wolffian tumors | Four distinct patterns: diffuse or solid, tubular, retiform and multicystic, cells with low mitotic count | CK, Vim, CD10, AR +; EMA, ER, PR −/only focal +; GATA-3 −/ weak multifocal +; CK7, CR, WT-1, inhibin-α, FOXL-2 focal +; SF-1 − | PAS + | NS |
Lymphangioma | Consist of cavernous or cystic dilated lymphatics | CK −; Vim, CD34, CD31, FVIII, D2-40 + | NS | NS |