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Table 4 Association of BMI change between age 20 and joining PROCAS with all-cause mortality (all ages)

From: Obesity at age 20 and weight gain during adulthood increase risk of total and premature all-cause mortality: findings from women attending breast screening in Manchester

BMI category age 20

BMI category at PROCAS entry

Number

Number of deaths (%)

Model 1

Model 2

HR (95% CI)

HR (95% CI)

Underweight or healthy weight

Underweight or healthy weight

18,300

590 (3.2)

1 (reference)

1 (reference)

 

Overweight

15,607

544 (3.5)

1.01 (0.90–1.14)

0.94 (0.83–1.05)

 

Obese

8419

375 (4.5)

1.38 (1.21–1.57)

1.16 (1.02–1.32)

Overweight

Underweight or healthy weight

525

34 (6.5)

1.89 (1.34–2.68)

1.76 (1.25–2.49)

 

Overweight

1304

68 (5.2)

1.47 (1.15–1.89)

1.36 (1.06–1.75)

 

Obese

3203

141 (4.4)

1.47 (1.23–1.77)

1.22 (1.02–1.47)

Obese

Underweight or healthy weight

60

13 (21.7)

6.74 (3.89–11.67)

5.05 (2.91–8.76)

 

Overweight

187

16 (8.6)

3.45 (2.10–5.67)

2.83 (1.72–4.66)

 

Obese

975

60 (6.2)

2.49 (1.91–3.25)

1.90 (1.45–2.48)

  1. Cox regressions: Model 1 adjusted for age at consent; Model 2 adjusted for age at consent, deprivation level, bilateral oophorectomy, HRT, menopausal status, ethnicity, alcohol units per week, physical activity minutes per week. Reference categories: underweight or healthy weight at both time points, pre/perimenopausal, white ethnicity.
  2. Due to low numbers of women underweight at entry and the focus of the analyses on obesity, the underweight and healthy weight categories were combined.