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Table 5 Association of ICAM-1 mRNA expression with metabolic indices in cases (post OCP treated PCOS group)

From: Oral contraceptive pill (OCP) treatment alters the gene expression of intercellular adhesion molecule-1 (ICAM-1), tumor necrosis factor-α (TNF-α), monocyte chemoattractant protein-1 (MCP-1) and plasminogen activator inhibitor-1 (PAI-1) in polycystic ovary syndrome (PCOS) women compared to drug-naive PCOS women

Gene

BMI Kg/m2

Mean ΔCT ± SD

Number

P value

ICAM-1

 ≥ 25

11.75 ± 1.01

15

 < 0.0001**

 < 25

13.79 ± 0.86

10

Blood glucose 2 h mg/dl

   

 ≥ 140

12.03 ± 1.03

16

0.0005**

 < 140

13.51 ± 0.48

9

Triglycerides

mg/dl

   

 < 150

13.81 ± 0.62

8

 < 0.0001**

 ≥ 150

11.73 ± 1.13

17

Fasting Insulin (µIU/ml)

   

 ≥ 10

11.64 ± 1.17

18

 < 0.0001**

 < 10

13.9 ± 0.81

7

2 Hr Insulin (µIU/ml)

   

 < 45

13.21 ± 0.54

9

0.02**

 ≥ 45

12.33 ± 1.01

16

  1. ICAM-1 Intercellular adhesion molecule-1, BMI Body mass index, CT Cycle threshold, SD Standard deviation