Does full HPV genotyping perform similarly well in clinician-collected cervical samples and self-collected vaginal samples when using the CLART HPV4S assay?

Table 1 Concordance and overall agreement for HPV detection (any type) between self-samples and clinician-collected samples (n = 212)

	Clinician-collected samples						κ^b	Agreement	Sensitivity	Specificity
	HPV positive^a		HPV negative		Total		κ^b	(%) (95% CI)	(%) (95% CI)	(%) 95% CI)
	n	%	n	%	n	%		(%) (95% CI)	(%) (95% CI)	(%) 95% CI)
Self-samples
HPV positive^a	28	13.2	13	6.1	41	19.3	0.63 (0.50–0.77)	88.7 (83.6–92.6)	71.8 (55.1–85.0)	92.5 (87.5–95.9)
HPV negative	11	5.2	160	75.5	171	80.7
Total	39	18.4	173	81.6	212	100

HPV human papillomavirus, CI confidence interval
^aHPV positive: Genotype 16, 18, 31, 33, 35, 39, 45, 51, 52, 56, 58, 59, 66 and 68
^bCohen’s Kappa: “Poor” (κ ≤ 0.20), “Fair” (0.21 ≤ κ ≤ 0.40), “Moderate” (0.41 ≤ κ ≤ 0.60), “Good” (0.61 ≤ κ ≤ 0.80), or “Very good” (κ ≥ 0.81) [21]. % = Row percentage

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