Table 2 Characteristics of studies investigating pre-eclampsia and risk of endometrial cancer
From: Pre-eclampsia during pregnancy and risk of endometrial cancer: a systematic review and meta-analysis
Author (Year) Location | Study Design | Study Cohort/ Database | Study Population | Recruitment Period | Study Size | Pre-eclampsia Ascertainment/ | Endometrial Cancer Ascertainment | Pre-eclampsia definition | No. Endometrial Cancer Cases | Follow-up (mean/median) | NOS score | Adjustments |
|---|---|---|---|---|---|---|---|---|---|---|---|---|
Liu et al.(35) (2021) China | Population-based retrospective case-control study | Wuxi Maternity and Child Health Hospital, Nanjing Medical University database | Women diagnosed with endometrial cancer and controls who had more than one live birth | 2013–2016 | 532 | Wuxi Maternity and Child Health Hospital database | Medical Records | SP ≥ 140mmHg and/or DP ≥ 90mmHg measured on two occasions separated by at least 6 h, with or without proteinuria, and/or impaired liver function and/or lower platelet count, after 20 weeks of gestation in accordance with the guidelines of the ISSHP. | 189 | Not stated | 5/9 | None listed |
Trabert et al. (20) (2020) Nordic countries Denmark, Finland, Norway, Sweden | Population-based nested case-control study | Denmark, Finland, Norway, and Sweden Nationwide Health Registers | Women with a pregnancy lasting at least 22 weeks | Denmark: 1973–2011, Finland: 1987–2012, Norway: 1967–2013, Sweden: 1974–2013 | 134,673 | National patient and Birth Registries | National Cancer Registry | Not defined. | 10,924 | 46 years (maximum) | 9/9 | Country, Categorical birth year, Age at index date, Marital status at first birth, pre-pregnancy or early-pregnancy BMI at the last pregnancy, and parity. |
Cho et al. (34) (2019) South Korea | Retrospective population-based cohort study | Korea National Health Insurance (KNHI) claims database | Women who gave birth in 2007. | 2007 | 386,614 | KNHI database | KNHI database | Defined according to ICD-8 codes. | 75 | 8 years (maximum) | 7/9 | Age at birth, Advanced maternal age, Primiparity, Multifetal pregnancy, C/S, pre-eclampsia, postpartum haemorrhage, placental abruption, placenta previa, and uterine arterial, embolization |
Table 2cont’d: Characteristics of studies investigating pre-eclampsia and risk of endometrial cancer (continued) | ||||||||||||
Walfisch et al. (30) (2015) Southern Israel | Hospital-based retrospective cohort study | Soroka University Medical Center, Southern Israel | Women who delivered during the study period (1988–2013) | 1988–2013 | 103,180 | Peri-natal database | Hospital Records | New onset hypertension with proteinuria during pregnancy. | 57 | 11.6 years (mean) | 4/9 | None listed |
Bhattacharya et al.(31) (2012) United Kingdom (Aberdeen) | Retrospective population-based cohort study | The Aberdeen Maternity and Neonatal | Primiparous women born on/before 31st December 1967 | 1950–2007 | 25,791 | AMND database | Scottish Cancer Registry | Gestational hypertension (DP > 90mmHg on 2 occasions at least 4 h apart or a single reading of 110mmHg; from 20 weeks gestation onwards in a previously normotensive woman) Plus at least 1 episode of proteinuria of 0.3 g/24 h. | 194 | 1,109,329-woman years (maximum) | 8/9 | Year of birth, smoking status, social class of women at the time of first pregnancy |
Calderon-Margalit et al.(33) (2009) Western Jerusalem | Retrospective population-based cohort study | Jerusalem Perinatal study | Women with a pregnancy lasting at least 28 weeks | 1964–1976 | 37,927 | Birth notifications, Maternity wards logbooks | Israel Cancer Registry | Hypertension (SP > 140 mmHg and/or DP > 90 mmHg) proteinuria, and oedema. | 183 | 33.52 years (mean) | 7/9 | Age at first birth |
Mogren et al. (32) (2001) Sweden | Multi-centre retrospective cohort study | Västerbotten and Vasternorrland counties. | Primiparous women | 1955–1973 | 25,569 | Local Birth Registry | National Cancer Registry | Defined according to ICD-8 codes. | 102 | 41 years (maximum) | 7/9 | None listed |