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Table 3 Sub-group and sensitivity analyses investigating pre-eclampsia and risk of endometrial cancer

From: Pre-eclampsia during pregnancy and risk of endometrial cancer: a systematic review and meta-analysis

Sub-group analyses

No. of included studies

Pooled risk estimate

(95% CI)

I-squared

P-value

(Heterogeneity)

Main analysis

7

1.07 (0.79–1.46)

34.1%

0.17

Studies with a quality score ≥ 7

5

1.05(0.72–1.54)

50.7%

0.08

Studies with a quality score of < 7

2

0.90(0.39–2.08)

0.0%

0.99

Restricted to studies adjusting for potential confounding factors

4

1.01(0.61–1.67)

58.1%

0.06

Risk of endometrial neoplasiaa

7

1.34(1.15–1.57)

29.6%

0.20

Summary of pooled results removing individual studies investigating pre-eclampsia and risk of endometrial cancer

Excluding Liu et al. (2021)

6

1.06(0.75–1.48)

42.9%

0.12

Excluding Trabert et al. (2020)

6

0.85(0.60–1.21)

0%

0.92

Excluding Cho et al. (2019)

6

1.12(0.84–1.49)

31.7%

0.19

Excluding Walfisch et al. (2015)

6

1.07(0.76–1.50)

40.8%

0.13

Excluding Bhattacharya et al. (2012)

6

1.40(1.26–1.54)

0%

0.42

Excluding Calderon-Margalit et al. (2009

6

1.07(0.76–1.51)

39.1%

0.15

Excluding Mogren et al. (2001)

6

1,04(0.71–1.52)

38.9%

0.15

  1. a Result from Cho et al. (2019) [31] included atypical endometrial hyperplasia, carcinoma in situ of the endometrium or endometrial cancer