| Cause-specific survival | Overall survival | ||||||
---|---|---|---|---|---|---|---|---|
 | Univariate analysis | Multivariate analysis | Univariate analysis | Multivariate analysis | ||||
Characteristics | HR (95% CI) | P | HR (95% CI) | P | HR (95% CI) | P | HR (95% CI) | P |
Adjuvant treatment | ||||||||
 CRT | Reference |  |  |  | Reference |  |  |  |
 CT alone | 1.96 (1.81–2.12) |  < 0.001 | 1.25 (1.14–1.37) |  < 0.001 | 1.90 (1.76–2.05) |  < 0.001 | 1.27 (1.17–1.38) |  < 0.001 |
Age group (years) | ||||||||
  < 50 | Reference |  |  |  | Reference |  |  |  |
 50–65 | 0.99 (0.77–1.26) | 0.908 | 1.27 (0.99–1.62) | 0.058 | 0.99 (0.78–1.25) | 0.917 | 1.27 (1.08–1.61) | 0.044 |
  > 65 | 1.16 (0.91–1.42) | 0.221 | 1.53 (1.19–1.95) | 0.001 | 1.25 (0.99–1.57) | 0.062 | 1.62 (1.28–2.05) |  < 0.001 |
Year of diagnosis | ||||||||
 2004–2008 | Reference |  |  |  | Reference |  |  |  |
 2009–2013 | 0.78 (0.69–0.86) |  < 0.001 | 0.84 (0.76–0.94) | 0.002 | 0.80 (0.72–0.88) |  < 0.001 | 0.87 (0.78–0.96) | 0.006 |
 2014–2018 | 0.69 (0.62–0.76) |  < 0.001 | 0.726 (0.649–0.812) |  < 0.001 | 0.71 (0.64–0.78) |  < 0.001 | 0.75 (0.68–0.84) |  < 0.001 |
Race recode | ||||||||
 Black | Reference |  |  |  | Reference |  |  |  |
 Othersa | 0.74 (0.63–0.86) |  < 0.001 | 0.68 (0.58–0.80) |  < 0.001 | 0.76 (0.66–0.88) |  < 0.001 | 0.72 (0.62–0.83) |  < 0.001 |
 White | 0.87 (0.79–0.96) | 0.003 | 0.85 (0.77–0.93) | 0.001 | 0.87 (0.79–0.95) | 0.001 | 0.85 (0.80–0.93) |  < 0.001 |
Marital status | ||||||||
 Divorced/separated | Reference |  |  |  | Reference |  |  |  |
 Married | 0.88 (0.78–0.98) | 0.026 | 0.95 (0.85–1.07) | 0.438 | 0.85 (0.76–0.95) | 0.005 | 0.93 (0.8301.04) | 0.199 |
 Single/unmarried | 1.09 (0.88–1.16) | 0.915 | 0.97 (0.84–1.12) | 0.655 | 0.98 (0.86–1.12) | 0.794 | 0.96 (0.84–1.09) | 0.502 |
 Unknown | 0.76 (0.61–0.96) | 0.018 | 0.89 (0.71–1.12) | 0.310 | 0.81 (0.65–0.99) | 0.041 | 0.93 (0.76–1.15) | 0.516 |
 Widowed | 1.13 (0.98–1.29) | 0.095 | 1.018 (0.883–1.172) | 0.809 | 1.18 (1.04–1.34) | 0.012 | 1.06 (0.93–1.21) | 0.413 |
Median household income | ||||||||
 < $50,000 | Reference |  |  |  | Reference |  |  |  |
 $50,000–65,000 | 1.01 (0.89–1.16) | 0.908 | 1.11 (0.98–1.26) | 0.115 | 0.98(0.87–1.11) | 0.738 | 1.07 (0.95–1.21) | 0.257 |
  > $65,000 | 0.90 (0.80–1.01) | 0.077 | 0.99 (0.88–1.12) | 0.887 | 0.85(0.76–0.96) | 0.006 | 0.94 (0.84–1.05) | 0.270 |
Grade | ||||||||
 I | Reference |  |  |  | Reference |  |  |  |
 II | 1.14 (0.70–1.86) | 0.588 | 1.10 (0.68–1.79) | 0.698 | 1.07 (0.70–1.64) | 0.750 | 1.05 (0.69–1.61) | 0.814 |
 III | 1.68 (1.09–2.58) | 0.019 | 1.42 (0.92–2.19) | 0.115 | 1.40 (0.96–2.04) | 0.076 | 1.20 (0.83–1.76) | 0.333 |
 IV | 1.65 (1.07–2.55) | 0.023 | 1.38 (0.89–2.13) | 0.149 | 1.41 (0.97–2.06) | 0.073 | 1.20 (0.82–1.75) | 0.354 |
 Unknown | 1.52 (0.98–2.34) | 0.062 | 1.22 (0.79–1.89) | 0.381 | 1.31 (0.90–1.92) | 0.160 | 1.07 (0.73–1.57) | 0.715 |
Histology | ||||||||
 Clear cell | Reference |  |  |  | Reference |  |  |  |
 Serous | 1.12 (0.99–1.27) | 0.083 | 1.07 (0.94–1.21) | 0.322 | 1.08 (0.96–1.21) | 0.225 | 1.03 (0.92–1.16) | 0.610 |
 Carcinosarcoma | 1.73 (1.47–2.03) |  < 0.001 | 1.90 (1.597–2.252) |  < 0.001 | 1.67 (1.43–1.94) |  < 0.001 | 1.81 (1.54–2.13) |  < 0.001 |
TNM stage | ||||||||
 T1N0M0 | Reference |  |  |  | Reference |  |  |  |
 T2N0M0 | 2.20 (1.78–2.71) |  < 0.001 | 2.11 (1.71–2.61) |  < 0.001 | 2.09 (1.73–2.537) |  < 0.001 | 2.02 (1.67–2.44) |  < 0.001 |
 T3-4aN0MO | 3.74 (3.20–4.36) |  < 0.001 | 3.43 (2.933–4.013) |  < 0.001 | 3.30 (2.87–3.79) |  < 0.001 | 3.05 (2.64–3.52) |  < 0.001 |
 TanyN1M0 | 4.22 (3.67–4.86) |  < 0.001 | 4.12 (3.566–4.766) |  < 0.001 | 3.86 (3.40–4.38) |  < 0.001 | 3.78 (3.32–4.31) |  < 0.001 |
 TanyN2M0 | 5.58 (4.40–7.08) |  < 0.001 | 5.21 (4.082–6.648) |  < 0.001 | 4.78 (3.80–6.00) |  < 0.001 | 4.43 (3.51–5.60) |  < 0.001 |
 TanyNanyM1 | 10.62(9.32–12.10) |  < 0.001 | 8.02 (6.964–9.235) |  < 0.001 | 9.06 (8.05–10.20) |  < 0.001 | 6.85 (6.03–7.79) |  < 0.001 |
Surgery mode | ||||||||
 Total hysterectomy | Reference |  |  |  | Reference |  |  |  |
 Extended hysterectomy | 1.53 (1.37–1.71) |  < 0.001 | 1.14 (1.02–1.28) | 0.021 | 1.49 (1.34–1.66) |  < 0.001 | 1.13 (1.06–1.26) | 0.026 |
Lymphadenectomy | ||||||||
 Yes | Reference |  |  |  | Reference |  |  |  |
 No | 2.33 (2.15–2.53) |  < 0.001 | 1.47 (1.34–1.61) |  < 0.001 | 2.24 (2.07–2.42) |  < 0.001 | 1.45 (1.32–1.58) |  < 0.001 |
 SLN biopsy/removed | 0.86 (0.69–1.07) | 0.182 | 1.02 (0.81–1.28) | 0.883 | 0.85 (0.70–1.05) | 0.137 | 0.99 (0.80–1.24) | 0.970 |
Tumor Size (mm) | ||||||||
  < 20 | Reference |  |  |  | Reference |  |  |  |
 20–39 | 1.30 (1.11–1.53) | 0.001 | 1.08 (0.92–1.26) | 0.378 | 1.31 (1.13–1.53) |  < 0.001 | 1.10 (0.94–1.28) | 0.241 |
 40–59 | 1.72 (1.47–2.02) |  < 0.001 | 1.26 (1.07–1.48) | 0.006 | 1.70 (1.46–1.97) |  < 0.001 | 1.24 (1.07–1.45) | 0.005 |
 60–79 | 2.21 (1.87–2.63) |  < 0.001 | 1.27 (1.07–1.52) | 0.007 | 2.22 (1.89–2.61) |  < 0.001 | 1.29(1.10–1.53) | 0.002 |
  ≥ 80 | 2.80 (2.37–3.32) |  < 0.001 | 1.39 (1.17–1.66) |  < 0.001 | 2.80 (2.39–3.29) |  < 0.001 | 1.43 (1.21–1.69) |  < 0.001 |
 Unknown | 1.82 (1.56–2.11) |  < 0.001 | 1.18 (1.01–1.37) | 0.041 | 1.82 (1.58–2.10) |  < 0.001 | 1.21 (1.05–1.40) | 0.010 |