Table 4 Estimated five-year OS and CSS in endometrial serous carcinoma stratified by TNM stages and adjuvant treatments

T1N0M0

1932

84.64%(82.67–86.41)

81.41%(79.32–83.32)

 EBRT + CT

150

84.17% (75.77–89.86)

Reference

82.24% (73.53–88.31)

Reference

 CT alone

732

84.96% (81.59–87.76)

1.037 (0.620–1.734)

0.889

81.93% (78.38–84.96)

1.131 (0.698–1.835)

0.617

 EBRT alone

103

70.84% (59.45–79.56)

2.281 (1.220–4.264)

0.010

64.96% (53.59–74.20)

2.507 (1.406–4.470)

0.002

 VBT alone

155

87.19% (78.87–92.39)

0.921 (0.453–1.872)

0.820

77.76% (68.15–84.79)

1.457 (0.796–2.666)

0.223

 EBRT + VBT

46

76.67% (58.17–87.79)

1.257 (0.540–2.922)

0.596

74.73% (56.51–86.18)

1.256 (0.567–2.782)

0.574

 VBT + CT

692

85.04% (81.12–88.21)

0.999 (0.588–1.699)

0.998

82.93% (78.92–86.24)

1.068 (0.648–1.760)

0.796

 EBRT + VBT + CT

54

79.93% (63.26–89.62)

1.189 (0.514–2.753)

0.686

74.60% (57.47–85.64)

1.384 (0.644–2.974)

0.405

T2N0M0

425

63.82%(58.47–68.68)

59.37%(54.02–64.31)

 EBRT + CT

63

62.81% (45.27–76.11)

Reference

57.96% (41.51–71.30)

Reference

 CT alone

124

65.01% (54.33–73.78)

1.053 (0.582–1.902)

0.865

60.71% (50.26–69.62)

0.987 (0.578–1.685)

0.961

 EBRT alone

32

52.41% (32.10–69.25)

1.648 (0.792–3.426)

0.181

42.36% (24.46–59.22)

1.730 (0.906–3.303)

0.097

 VBT alone

20

59.27% (34.74–77.20)

1.395 (0.596–3.262)

0.443

55.00% (31.34–73.49)

1.260 (0.573–2.771)

0.565

 EBRT + VBT

22

62.15% (33.39–81.37)

0.927 (0.363–2.370)

0.874

56.06% (28.55–76.55)

0.865 (0.366–2.047)

0.741

 VBT + CT

104

61.36% (49.08–71.52)

1.032 (0.562–1.893)

0.919

58.70% (46.43–69.07)

0.882 (0.504–1.542)

0.659

 EBRT + VBT + CT

60

63.63% (46.53–76.56)

1.047 (0.518–2.119)

0.897

62.34% (45.51–75.30)

0.894 (0.463–1.725)

0.738

T3-4aN0M0

721

51.77% (47.77–55.61)

48.43%(44.49–52.25)

 EBRT + CT

138

47.04% (37.16–56.30)

44.45% (34.91–53.55)

 CT alone

347

47.55% (41.57–53.28)

0.945 (0.696–1.284)

0.719

45.05% (39.20–50.72)

0.936 (0.695–1.261)

0.664

 EBRT alone

30

45.28% (22.55–61.30)

0.847 (0.463–1.547)

0.588

33.77% (17.33–51.05)

0.985 (0.573–1.692)

0.956

 VBT alone

9

23.47% (2.64–56.10)

1.340 (0.573–3.132)

0.499

20.00% (2.30–50.31)

1.456 (0.654–3.242)

0.357

 EBRT + VBT

9

47.27% (12.00–76.74)

0.578 (0.202–1.651)

0.306

47.27% (12.00–76.74)

0.504 (0.173–1.468)

0.209

 VBT + CT

117

68.24% (58.23–76.33)

0.595 (0.386–0.916)

0.018

65.50% (55.41–73.83)

0.584 (0.385–0.888)

0.012

 EBRT + VBT + CT

71

49.20% (34.22–62.55)

0.908 (0.572–1.441)

0.681

44.84% (30.50–58.17)

0.966 (0.621–1.503)

0.879

TanyN1-2M0

1220

47.64%(44.52–50.69)

43.64%(40.60–46.64)

 EBRT + CT

408

49.13% (43.08–54.88)

45.51% (39.65–51.18)

 CT alone

497

42.32% (37.23–47.31)

1.239 (1.012–1.518)

0.038

38.06% (33.19–42.91)

1.249 (1.029–1.514)

0.024

 EBRT alone

28

26.43% (9.27–47.49)

1.945 (1.180–3.205)

0.009

19.38% (6.00–38.41)

2.045 (1.273–3.286)

0.003

 VBT alone

3

3.132 (0.767–12.792)

0.112

4.391 (1.385–13.920)

0.012

 EBRT + VBT

15

55.78% (26.35–77.45)

0.958 (0.413–2.222)

0.920

36.43% (13.18–60.45)

1.279 (0.631–2.592)

0.496

 VBT + CT

96

53.94% (42.02–64.44)

0.863 (0.600–1.242)

0.429

51.19% (39.54–61.67)

0.851 (0.601–1.205)

0.364

 EBRT + VBT + CT

173

43.99% (34.38–53.17)

1.050 (0.789–1.396)

0.740

41.17% (31.82–50.26)

1.026 (0.779–1.350)

0.857

TanyNanyM1

1279

21.45% (19.11–23.89)

18.92%(16.72–21.24)

 EBRT + CT

118

23.63% (15.35–32.93)

Reference

21.88% (14.10–30.76)

 CT alone

1062

16.48% (13.75–19.42)

0.954 (0.752–1.208)

0.694

14.51% (12.02–17.22)

0.957 (0.760–1.206)

0.710

 EBRT alone

10

0

3.700 (1.901–7.199)

 < 0.001

0

3.538 (1.822–6.871)

 < 0.001

 VBT alone

1

0

7.639 (1.045–55.816)

0.045

0

7.644 (1.047–55.789)

0.045

 EBRT + VBT

2

0

4.994 (1.215–20.518)

0.026

0

4.853 (1.183–19.914)

0.028

 VBT + CT

55

22.81% (10.45–38.02)

0.656 (0.433–0.992)

0.046

21.83% (10.00–36.58)

0.657 (0.439–0.982)

0.041

 EBRT + VBT + CT

31

23.13% (8.84–41.33)

0.721 (0.444–1.170)

0.185

19.09% (6.46–36.76)

0.718 (0.447–1.152)

0.170