|  | Cause-specific survival | Overall survival | ||||
---|---|---|---|---|---|---|---|
TNM stage | Number | Estimate, % (95%CI) | Hazard ratio (95%CI) | P value | Estimate, % (95%CI) | Hazard ratio (95%CI) | P value |
T1N0M0 | 1932 | 84.64%(82.67–86.41) |  |  | 81.41%(79.32–83.32) |  |  |
 EBRT + CT | 150 | 84.17% (75.77–89.86) | Reference |  | 82.24% (73.53–88.31) | Reference |  |
 CT alone | 732 | 84.96% (81.59–87.76) | 1.037 (0.620–1.734) | 0.889 | 81.93% (78.38–84.96) | 1.131 (0.698–1.835) | 0.617 |
 EBRT alone | 103 | 70.84% (59.45–79.56) | 2.281 (1.220–4.264) | 0.010 | 64.96% (53.59–74.20) | 2.507 (1.406–4.470) | 0.002 |
 VBT alone | 155 | 87.19% (78.87–92.39) | 0.921 (0.453–1.872) | 0.820 | 77.76% (68.15–84.79) | 1.457 (0.796–2.666) | 0.223 |
 EBRT + VBT | 46 | 76.67% (58.17–87.79) | 1.257 (0.540–2.922) | 0.596 | 74.73% (56.51–86.18) | 1.256 (0.567–2.782) | 0.574 |
 VBT + CT | 692 | 85.04% (81.12–88.21) | 0.999 (0.588–1.699) | 0.998 | 82.93% (78.92–86.24) | 1.068 (0.648–1.760) | 0.796 |
 EBRT + VBT + CT | 54 | 79.93% (63.26–89.62) | 1.189 (0.514–2.753) | 0.686 | 74.60% (57.47–85.64) | 1.384 (0.644–2.974) | 0.405 |
T2N0M0 | 425 | 63.82%(58.47–68.68) |  |  | 59.37%(54.02–64.31) |  |  |
 EBRT + CT | 63 | 62.81% (45.27–76.11) | Reference |  | 57.96% (41.51–71.30) | Reference |  |
 CT alone | 124 | 65.01% (54.33–73.78) | 1.053 (0.582–1.902) | 0.865 | 60.71% (50.26–69.62) | 0.987 (0.578–1.685) | 0.961 |
 EBRT alone | 32 | 52.41% (32.10–69.25) | 1.648 (0.792–3.426) | 0.181 | 42.36% (24.46–59.22) | 1.730 (0.906–3.303) | 0.097 |
 VBT alone | 20 | 59.27% (34.74–77.20) | 1.395 (0.596–3.262) | 0.443 | 55.00% (31.34–73.49) | 1.260 (0.573–2.771) | 0.565 |
 EBRT + VBT | 22 | 62.15% (33.39–81.37) | 0.927 (0.363–2.370) | 0.874 | 56.06% (28.55–76.55) | 0.865 (0.366–2.047) | 0.741 |
 VBT + CT | 104 | 61.36% (49.08–71.52) | 1.032 (0.562–1.893) | 0.919 | 58.70% (46.43–69.07) | 0.882 (0.504–1.542) | 0.659 |
 EBRT + VBT + CT | 60 | 63.63% (46.53–76.56) | 1.047 (0.518–2.119) | 0.897 | 62.34% (45.51–75.30) | 0.894 (0.463–1.725) | 0.738 |
T3-4aN0M0 | 721 | 51.77% (47.77–55.61) |  |  | 48.43%(44.49–52.25) |  |  |
 EBRT + CT | 138 | 47.04% (37.16–56.30) |  |  | 44.45% (34.91–53.55) |  |  |
 CT alone | 347 | 47.55% (41.57–53.28) | 0.945 (0.696–1.284) | 0.719 | 45.05% (39.20–50.72) | 0.936 (0.695–1.261) | 0.664 |
 EBRT alone | 30 | 45.28% (22.55–61.30) | 0.847 (0.463–1.547) | 0.588 | 33.77% (17.33–51.05) | 0.985 (0.573–1.692) | 0.956 |
 VBT alone | 9 | 23.47% (2.64–56.10) | 1.340 (0.573–3.132) | 0.499 | 20.00% (2.30–50.31) | 1.456 (0.654–3.242) | 0.357 |
 EBRT + VBT | 9 | 47.27% (12.00–76.74) | 0.578 (0.202–1.651) | 0.306 | 47.27% (12.00–76.74) | 0.504 (0.173–1.468) | 0.209 |
 VBT + CT | 117 | 68.24% (58.23–76.33) | 0.595 (0.386–0.916) | 0.018 | 65.50% (55.41–73.83) | 0.584 (0.385–0.888) | 0.012 |
 EBRT + VBT + CT | 71 | 49.20% (34.22–62.55) | 0.908 (0.572–1.441) | 0.681 | 44.84% (30.50–58.17) | 0.966 (0.621–1.503) | 0.879 |
TanyN1-2M0 | 1220 | 47.64%(44.52–50.69) |  |  | 43.64%(40.60–46.64) |  |  |
 EBRT + CT | 408 | 49.13% (43.08–54.88) |  |  | 45.51% (39.65–51.18) |  |  |
 CT alone | 497 | 42.32% (37.23–47.31) | 1.239 (1.012–1.518) | 0.038 | 38.06% (33.19–42.91) | 1.249 (1.029–1.514) | 0.024 |
 EBRT alone | 28 | 26.43% (9.27–47.49) | 1.945 (1.180–3.205) | 0.009 | 19.38% (6.00–38.41) | 2.045 (1.273–3.286) | 0.003 |
 VBT alone | 3 |  | 3.132 (0.767–12.792) | 0.112 |  | 4.391 (1.385–13.920) | 0.012 |
 EBRT + VBT | 15 | 55.78% (26.35–77.45) | 0.958 (0.413–2.222) | 0.920 | 36.43% (13.18–60.45) | 1.279 (0.631–2.592) | 0.496 |
 VBT + CT | 96 | 53.94% (42.02–64.44) | 0.863 (0.600–1.242) | 0.429 | 51.19% (39.54–61.67) | 0.851 (0.601–1.205) | 0.364 |
 EBRT + VBT + CT | 173 | 43.99% (34.38–53.17) | 1.050 (0.789–1.396) | 0.740 | 41.17% (31.82–50.26) | 1.026 (0.779–1.350) | 0.857 |
TanyNanyM1 | 1279 | 21.45% (19.11–23.89) |  |  | 18.92%(16.72–21.24) |  |  |
 EBRT + CT | 118 | 23.63% (15.35–32.93) | Reference |  | 21.88% (14.10–30.76) |  |  |
 CT alone | 1062 | 16.48% (13.75–19.42) | 0.954 (0.752–1.208) | 0.694 | 14.51% (12.02–17.22) | 0.957 (0.760–1.206) | 0.710 |
 EBRT alone | 10 | 0 | 3.700 (1.901–7.199) |  < 0.001 | 0 | 3.538 (1.822–6.871) |  < 0.001 |
 VBT alone | 1 | 0 | 7.639 (1.045–55.816) | 0.045 | 0 | 7.644 (1.047–55.789) | 0.045 |
 EBRT + VBT | 2 | 0 | 4.994 (1.215–20.518) | 0.026 | 0 | 4.853 (1.183–19.914) | 0.028 |
 VBT + CT | 55 | 22.81% (10.45–38.02) | 0.656 (0.433–0.992) | 0.046 | 21.83% (10.00–36.58) | 0.657 (0.439–0.982) | 0.041 |
 EBRT + VBT + CT | 31 | 23.13% (8.84–41.33) | 0.721 (0.444–1.170) | 0.185 | 19.09% (6.46–36.76) | 0.718 (0.447–1.152) | 0.170 |