Association between low-dose pulsed intravenous cyclophosphamide therapy and amenorrhea in patients with systemic lupus erythematosus: A case-control study

Table 3 Incidence of amenorrhea in SLE patients in each age and treatment group

	With amenorrhea	Without amenorrhea	p*	OR (95% CI)
	n = 26	n = 36
Age < 40 years old
IVCY group^†	11 (42%)	10 (28%)	0.03	4.4 (1.3-15.2)
Steroid group^†	6 (23%)	24 (67%)	-	-
Age ≥ 40 years old
IVCY group^†	6 (23%)	2 (6%)	1.00	-
Steroid group^†	3 (12%)	0 (0%)	-	-

*p values were determined by Fisher's exact test.
^†Patients with SLE were divided into 2 groups: those who received low-dose IVCY plus high-dose glucocorticoids (IVCY group) and those who received high-dose glucocorticoids alone (steroid group).
IVCY intravenous cyclophosphamide, SLE systemic lupus erythematosus, OR odds ratio, CI confidence interval.

ISSN: 1472-6874