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Table 1 Environmental risk factors (MDCS, NSHDS and ICELAND)

From: Interactive effect of genetic susceptibility with height, body mass index, and hormone replacement therapy on the risk of breast cancer

Risk factor

Categories

MDCS

NSHDS

ICELAND

TOTAL

  

Count

OR*

Count

OR*

Count

OR*

Count

OR*

  

Case/Control

(95% CI)

Case/Control

(95% CI)

Case/Control

(95% CI)

Case/Control

(95% CI)

All individuals

BMI

Normal Weight

334/695

1

637/997

1

361/326

1

1332/2018

1

 

Over weight

237/450

1.26 (1.02-1.56)

439/701

0.99 (0.84-1.15)

241/312

0.76 (0.60-0.96)

917/1463

1.00 (0.90-1.12)

 

Obese

95/194

1.25 (0.94-1.66)

167/286

0.91 (0.74-1.14)

112/139

0.79 (0.59-1.07)

374/619

0.97 (0.84-1.13)

Height

<162 cm

207/471

1

398/722

1

171/173

1

776/1366

1

 

162-166 cm

233/443

1.03 (0.81-1.30)

445/657

1.21 (1.02-1.44)

289/307

0.92 (0.70-1.20)

967/1407

1.15 (1.02-1.30)

 

>166 cm

233/448

0.93 (0.73-1.18)

436/640

1.21 (1.01-1.44)

354/414

0.78 (0.60-1.02)

1023/1502

1.09 (0.97-1.23)

> 50 years

HRT

Non users

341/806

1

777/1320

1

66/286

1

1184/2412

1

 

Current users

181/256

1.26 (0.99-1.61)

186/295

1.09 (0.89-1.34)

105/225

2.06 (1.45-2.95)

424/776

1.22 (1.07-1.39)

BMI

Normal Weight

322/694

1

400/682

1

189/217

1

911/1593

1

 

Over weight

232/449

1.26 (1.02-1.57)

320/504

1.09 (0.91-1.32)

188/255

0.85 (0.65-1.12)

740/1208

1.12 (0.99-1.26)

 

Obese

95/194

1.26 (0.94-1.68)

130/205

1.10 (0.85-1.41)

86/109

0.91 (0.65-1.29)

311/508

1.13 (0.96-1.34)

Height

<162 cm

205/471

1

283/534

1

125/136

1

613/1141

1

 

162-166 cm

224/442

1.02 (0.81-1.29)

311/458

1.26 (1.03-1.55)

198/244

0.88 (0.64-1.19)

733/1144

1.13 (0.99-1.30)

 

>166 cm

227/447

0.94 (0.74-1.19)

279/421

1.22 (0.99-1.51)

199/274

0.78 (0.57-1.06)

705/1142

1.05 (0.92-1.21)

  1. *Adjusted for age.