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Table 4 OR adjusted for Age and Study Population, stratified by HRT

From: Interactive effect of genetic susceptibility with height, body mass index, and hormone replacement therapy on the risk of breast cancer

SNP rs nr

Genotype

p-value for interaction

All individuals*

HRT Non Users*

HRT Current Users*

HRT Estrogen*

HRT Comb*

   

case/contr: 2869/4480

case/contr: 1536/2949

case/contr: 494/800

case/contr: 185/324

case/contr:298/455

   

OR 95%CI

p-trend

OR 95%CI

p-trend

OR 95%CI

p-trend

OR 95%CI

p-trend

OR 95%CI

p-trend

FGFR2 2981582

AA

 

1

 

1

 

1

 

1

 

1

 
 

Aa

 

1.23 (1.10-1.37)

 

1.22 (1.06-1.41)

 

1.16 (0.89-1.50)

 

1.15 (0.75-1.75)

 

1.17 (0.83-1.65)

 
 

aa

 

1.48 (1.29-1.69)

 

1.55 (1.29-1.89)

 

1.63 (1.17-2.26)

 

1.44 (0.86-2.42)

 

1.87 (1.21-2.89)

 
 

Per Allele

0,83

1.22 (1.14-1.30)

1.34E-08

1.24 (1.14-1.36)

2.04E-06

1.26 (1.07-1.49)

4.83E-03

1.20 (0.92-1.55)

0.18

1.34 (1.08-1.66)

7.30E-03

TNRC9 3803662

AA

 

1

 

1

 

1

 

1

 

1

 
 

Aa

 

1.14 (1.03-1.26)

 

1.15 (1.01-1.31)

 

1.17 (0.91-1.49)

 

1.31 (0.89-1.94)

 

1.13 (0.83-1.56)

 
 

aa

 

1.39 (1.17-1.67)

 

1.48 (1.18-1.86)

 

1.47 (0.96-2.27)

 

1.56 (0.79-3.11)

 

1.53 (0.86-2.69)

 
 

Per Allele

0,98

1.16 (1.08-1.25)

5.34E-05

1.19 (1.08-1.31)

3.74E-04

1.19 (1.00-1.43)

0.05

1.28 (0.96-1.70)

0.09

1.19 (0.94-1.51)

0.15

MAP3K1 889312

AA

 

1

 

1

 

1

 

1

 

1

 
 

Aa

 

1.21 (1.09-1.34)

 

1.27 (1.11-1.45)

 

1.04 (0.82-1.32)

 

0.87 (0.59-1.29)

 

1.13 (0.82-1.54)

 
 

aa

 

1.29 (1.09-1.54)

 

1.20 (0.95-1.53)

 

1.54 (1.02-2.33)

 

1.81 (0.98-3.33)

 

1.31 (0.74-2.33)

 
 

Per Allele

0,12

1.17 (1.08-1.26)

4.26E-05

1.17 (1.06-1.29)

1.90E-03

1.15 (0.97-1.38)

0.11

1.16 (0.88-1.52)

0.28

1.14 (0.90-1.44)

0.29

8q24 13281615

AA

 

1

 

1

 

1

 

1

 

1

 
 

Aa

 

1.12 (1.00-1.24)

 

1.20 (1.04-1.39)

 

1.05 (0.81-1.34)

 

0.90 (0.60-1.36)

 

1.10 (0.80-1.53)

 
 

aa

 

1.15 (1.00-1.32)

 

1.43 (1.20-1.71)

 

0.86 (0.61-1.20)

 

0.88 (0.52-1.51)

 

0.84 (0.53-1.32)

 
 

Per Allele

0,03

1.08 (1.01-1.15)

0.03

1.20 (1.10-1.31)

6.10E-05

0.95 (0.81-1.12)

0.52

0.93 (0.72-1.22)

0.61

0.95 (0.77-1.18)

0.67

LSP1 3817198

AA

 

1

 

1

 

1

 

1

 

1

 
 

Aa

 

1.12 (1.02-1.24)

 

1.13 (0.99-1.29)

 

1.29 (1.01-1.65)

 

1.32 (0.89-1.94)

 

1.30 (0.95-1.80)

 
 

aa

 

1.19 (1.00-1.40)

 

1.06 (0.85-1.31)

 

1.68 (1.12-2.53)

 

1.19 (0.61-2.33)

 

2.35 (1.37-4.03)

 
 

Per Allele

0,13

1.10 (1.02-1.18)

8.65E-03

1.06 (0.97-1.17)

0.21

1.30 (1.09-1.55)

4.07E-03

1.18 (0.89-1.56)

0.26

1.44 (1.14-1.82)

2.16E-03

2q35

AA

 

1

 

1

 

1

 

1

 

1

 
 

Aa

 

1.05 (0.93-1.19)

 

1.05 (0.89-1.23)

 

0.95 (0.72-1.27)

 

0.77 (0.48-1.25)

 

1.13 (0.78-1.63)

 
 

aa

 

1.20 (1.05-1.37)

 

1.15 (0.97-1.38)

 

1.20 (0.87-1.67)

 

1.26 (0.75-2.10)

 

1.20 (0.78-1.85)

 
 

Per Allele

0,68

1.10 (1.03-1.17)

7.47E-03

1.08 (0.98-1.17)

0.11

1.10 (0.93-1.29)

0.26

1.14 (0.88-1.48)

0.33

1.10 (0.88-1.36)

0.40

ESR1 7766585

AA

 

1

 

1

 

1

 

1

 

1

 
 

Aa

 

1.23 (1.10-1.37)

 

1.23 (1.07-1.43)

 

1.05 (0.81-1.36)

 

1.31 (0.85-2.03)

 

0.88 (0.63-1.23)

 
 

aa

 

1.02 (0.74-1.41)

 

1.01 (0.67-1.53)

 

1.29 (0.61-2.73)

 

1.43 (0.52-3.93)

 

0.86 (0.26-2.81)

 
 

Per Allele

0,47

1.16 (1.05-1.27)

2.66E-03

1.15 (1.02-1.31)

0.02

1.07 (0.86-1.34)

0.53

1.26 (0.89-1.79)

0.19

0.89 (0.66-1.21)

0.46

HCN1 981782

AA

 

1

 

1

 

1

 

1

 

1

 
 

Aa

 

0.97 (0.87-1.09)

 

0.88 (0.76-1.02)

 

1.15 (0.86-1.53)

 

0.88 (0.57-1.38)

 

1.34 (0.92-1.96)

 
 

aa

 

0.86 (0.75-0.99)

 

0.80 (0.66-0.95)

 

0.93 (0.66-1.31)

 

0.74 (0.43-1.28)

 

1.05 (0.67-1.64)

 
 

Per Allele

0,26

0.93 (0.87-1.00)

0.04

0.89 (0.81-0.98)

0.01

0.97 (0.82-1.14)

0.70

0.86 (0.66-1.13)

0.28

1.02 (0.82-1.27)

0.84

ESR1 851987

AA

 

1

 

1

 

1

 

1

 

1

 
 

Aa

 

0.91 (0.82-1.02)

 

0.94 (0.82-1.07)

 

0.80 (0.62-1.04)

 

0.94 (0.63-1.43)

 

0.73 (0.52-1.03)

 
 

aa

 

0.88 (0.74-1.05)

 

0.90 (0.72-1.13)

 

0.93 (0.62-1.42)

 

0.88 (0.46-1.68)

 

0.96 (0.54-1.69)

 
 

Per Allele

0,52

0.93 (0.86-1.00)

0.06

0.94 (0.86-1.04)

0.24

0.90 (0.75-1.09)

0.28

0.94 (0.70-1.25)

0.67

0.87 (0.68-1.12)

0.29

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