Skip to main content

Table 2 Number needed to treat for at least 50% pain relief

From: Rofecoxib for dysmenorrhoea: meta-analysis using individual patient data

   Improved with % improved   
Number of trials Drug and dose (mg) Active Placebo Active Placebo Relative risk (95% CI) NNT (95% CI)
Six hour ourcomes
   1 Rofecoxib 25 66/115 45/118 57 38 1.5 (1.1 to 2.0) 5.0 (3.7 to 7.8)
   3 Rofecoxib 50 140/226 70/225 62 31 2.0 (1.6 to 2.5) 3.2 (2.4 to 4.5)
   1 Ibuprofen 400 31/49 10/47 63 21 3.0 (1.7 to 5.4) 2.4 (1.7 to 4.2)
   2 Naproxen sodium 550 120/181 60/178 66 34 2.0 (1.6 to 2.5) 3.1 (2.4 to 4.4)
Eight hour ourcomes
   1 Rofecoxib 25 70/115 44/118 61 37 1.6 (1.2 to 2.2) 4.2 (2.8 to 9.0)
   3 Rofecoxib 50 147/226 73/225 65 32 2.0 (1.6 to 2.5) 3.1 (2.4 to 9.0)
   1 Ibuprofen 400 30/47 11/47 61 21 2.6 (1.5 to 4.6) 2.6 (1.8 to 5.1)
   2 Naproxen sodium 550 121/181 62/178 68 35 2.0 (1.6 to 2.4) 3.0 (2.3 to 4.3)
Twelve hour ourcomes
   1 Rofecoxib 25 64/115 45/118 56 38 1.5 (1.1 to 1.9) 5.7 (3.3 to 20)
   3 Rofecoxib 50 135/226 74/225 60 33 1.8 (1.5 to 2.3) 3.7 (2.8 to 5.6)
   1 Ibuprofen 400 27/49 12/47 55 26 2.2 (1.3 to 3.7) 3.4 (2.1 to 9.2)
   2 Naproxen sodium 550 111/181 62/178 61 35 1.8 (1.4 to 2.2) 3.8 (2.7 to 6.1)