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Table 4 Multivariate analysis of risk factors and HER-2/neu overexpression according to ER1 status.

From: Correlation of breast cancer risk factors with HER-2/neu protein overexpression according to menopausal and estrogen receptor status

Risk Factors HER-2/neu+ Cases/controls OR2 (95% CI3) HER-2/neu-Cases/controls OR (95% CI) Ratio of the OR's Cases+/cases- OR (95% CI)
ER + cases
Body mass index(>29 kg/m2) 5.59 (2.58–12.13) 2.84 (1.52–5.32) NS
Age at 1st pregnancy (≥ 23 years) 2.09 (0.97–4.53) NS NS
First degree family history (positive) NS 2.18 (0.92–5.14) NS
Abortion or miscarriage (ever) 0.44 (0.20–0.95) 0.56 (0.32–0.99) NS
ER – cases
Body mass index(>29 kg/m2) 5.33 (2.59–10.94) 2.41 (1.15–5.04) 2.46 (0.97–6.21)
Age at 1st pregnancy (≥ 23 years) 2.37 (1.08–5.18) 1.78 (0.93–3.42) NS
First degree family history (positive) NS 2.72 (1.05–7.07) NS
Age of menopause (>50 years) NS 2.05 (1.10–3.79) NS
Parity (1–2 children) NS 2.38 (1.21–4.67) NS
  1. Adjusted for age, residence, menopausal status, menopausal age, menarche age, use of OC, use of HRT, first degree family history, age at first full pregnancy, parity, abortion, lactation, medication to suppress lactation, radiation to the chest, body mass index and benign breast disease.
  2. 1ER: estrogen receptor. NS: non significant.