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Figure 4 | BMC Women's Health

Figure 4

From: Increased capsaicin receptor TRPV1 in skin nerve fibres and related vanilloid receptors TRPV3 and TRPV4 in keratinocytes in human breast pain

Figure 4

TRPV4-immunoreactivity in breast skin. TOP FOUR PANELS: TRPV4-immunoreactivity in keratinocytes mostly at the cell membrane and graded from grade 0/negative (top left) to grade 3/strong staining (bottom right). Scale bar = 100 μm MIDDLE PANEL: Fine, sub-epidermal, TRPV4-immunoreactive fibres (arrows). Scale bar = 100 μm BOTTOM PANELS: Scattergrams showing grading assessment of sub-epidermal fibres (left panel) and keratinocytes (right panel) significantly increased (*P < 0.05) in patients with pain.

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