Aberrations of TACC1 and TACC3 are associated with ovarian cancer

BMC Women's Health

Table 1 Distribution of TACC1 and TACC3 expression in ovarian tumors

Tumor type	TACC3^a				TACC1^a				TACC3 & TACC1^b
	Tumor grades^c				Tumor grades^c				Tumor grades^c
	I	II	III	all	I	II	III	all	all
serous papillary	1^d (7)^e 14.3%^f	6 (18) 33.3%	2 (17) 11.8%	9 (42) 21.4%	6 (7) 85.7%	13 (18) 72.2%	11 (17) 64.7%	30 (42) 71.4%	6 (42) 14.3%
mucinous	1 (3) 33.3%	0 (1) 0%	1 (1) 100%	2 (5) 40%	1 (3) 33.3%	1 (1) 100%	1 (1) 100%	3 (5) 60%	2 (5) 40%
endometroid	3 (5) 60%	0 (1) 0%	0 (1) 0%	3 (7) 42.8%	2 (5) 40%	0 (1) 0%	0 (1) 0%	2 (7) 28.6%	1 (7) 14.3%
clear cell^g			7(11) 63.6%	7 (11) 63.6%			6 (11) 54.5%	6 (11) 54.5%	5 (11) 45.5%
all types	5 (15) 33.3%	6 (20) 30.0%	10 (30) 33.3%	21(65) 32.3%	9 (15) 60.0%	14 (20) 70.0%	18 (30) 60.0%	41 (65) 63.1%	14 (65) 21.5%

^aExpression irrespective of the status of the other TACC protein;
^bTumor cores expressing both proteins;
^cSixty five cores could be graded (1,2,3) and scored for TACC1 and TACC3 expression. Tumors with less than 10% of cells stained were classed as negative (-), greater than 10%, as positive (+). Percentage expression was calculated within each histological subtype.
^dNumber of positive cores in a set;
^eTotal number of cores in a set;
^fPercentage of positive cores in a set;
^gClear cell carcinomas cannot be graded using the World Health Organisation or FIGO systems [13], but are classified as grade 3, as recommended by the NCCN practice guidelines [14].

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