Breast cancer risk and genetic ancestry: a case–control study in Uruguay

BMC Women's Health

Table 3 Association of nuclear and mitochondrial ancestry with breast cancer risk in Uruguayan women

Nuclear ancestry	OR^a	95% CI	p-value
European	1.05	(0.85,1.30)	0.63
African	1.09	(0.89,1.33)	0.42
Native American	0.84	(0.68,1.04)	0.10
N	312
Mitochondrial ancestry	OR ^b	95% CI	p-value
European	Reference		0.25^c
African	0.54	(0.22,1.33)	0.18
Native American	0.71	(0.42,1.20)	0.20
N	312
No H haplogroup	Reference
H haplogroup	1.99	(1.13,3.51)	0.02
N	312
No H haplogroup	Reference
H haplogroup	1.84	(0.97,3.51)	0.06
N^d	171

All regression models were adjusted for age, education and hospital. Mitochondrial ancestry regression models were additionally adjusted for European nuclear ancestry.
^aBreast cancer OR per 25% increase in ancestry.
^bBreast cancer OR for women carrying an African or Native American mitochondrial haplogroup compared to women carrying a European haplogroup, or women carrying a H haplogroup compared to those carrying a different haplogroup.
^cP-value for the model.
^dAnalysis restricted to women carrying a European mitochondrial haplogroup.

ISSN: 1472-6874