Gene polymorphisms in RANKL/RANK/OPG pathway are associated with ages at menarche and natural menopause in Chinese women

Table 4 The associations of haplotypes of TNFSF11, TNFRSF11A and TNFRSF11B genes with AAM and AANM

Gene	Haplotype	Frequency	AAM		AANM
Gene	Haplotype	Frequency	Beta	P	Beta	P
TNFSF11: rs9525641-rs2277439-rs2324851-rs2875459-rs2200287-rs9533166
	TAGTAC	0.131	−0.1686	0.24	−0.2171	0.46
	TAGTAT	0.088	0.0148	0.93	0.2392	0.50
	TGACGT	0.292	−0.0737	0.49	0.1958	0.38
	CAGCGT	0.469	0.0773	0.44	−0.1007	0.63
	TAGCGT	0.017	0.7854	0.06	−1.3300	0.09
TNFRSF11A: rs9962159-rs4603673
	AG	0.161	−0.1455	0.28	−0.2432	0.38
	GC	0.434	0.1294	0.18	−0.4383	0.03
	AC	0.405	−0.0578	0.55	0.5747	<0.01
TNFRSF11A : rs6567270-rs1805034
	TC	0.288	−0.2787	0.01	0.0069	0.98
	AT	0.408	0.2263	0.02	0.1197	0.55
	TT	0.305	−0.0113	0.91	−0.1408	0.51
TNFRSF11B : rs1485286-rs11573869-rs3102728-rs11573819-rs2073618
	TATGG	0.250	0.0311	0.78	0.2791	0.24
	CATAC	0.155	0.0770	0.57	−0.1808	0.52
	CACGC	0.139	0.0726	0.61	−0.2352	0.43
	CGTGC	0.164	−0.0407	0.76	0.1067	0.70
	TATGC	0.154	0.0955	0.48	0.0410	0.88
	CATGC	0.130	−0.2041	0.17	−0.1828	0.56

The analyses were performed under an additive model adjusted for age at interview and BMI. Beta, regression coefficient.

ISSN: 1472-6874