Preinvasive and invasive disease in women with cytological diagnosis of high-grade lesion and high-grade lesion cannot exclude microinvasion

Table 3 Prevalence of preinvasive or invasive disease by study group (IFF/Fiocruz-INCA, RJ, Brazil, 2006–2012)

Final diagnosis^a	Preinvasive or invasive lesion^b	Absence of preinvasive or invasive lesion^c	Total n (%)	Prevalence Ratio (PR) (CI 95 %)
Pap smear diagnosis
HSIL-Micro^d	45	2	47	6.5 (1.6 - 25.7)
HSIL^e	136	52	188	<0.001
Total	181	54	235

^aRecategorized diagnoses obtained at the end of investigation considering histopathological specimens. Negative cases were based on absence of visible colposcopic findings and two negative cytopathologic exams with a minimum of six-month intervals
^bIncludes CIN 2, CIN 3, adenocarcinoma in situ and microinvasive or invasive squamous carcinoma of the cervix
^cIncludes negative diagnoses, HPV cytopathic effect and CIN 1
^dHigh-grade intraepithelial lesion cannot exclude microinvasion
^eHigh-grade intraepithelial lesion

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