High prevalence of vitamin D deficiency among women of child-bearing age in Lahore Pakistan, associating with lack of sun exposure and illiteracy

Table 3 Genetic determinants of vitamin D status in healthy adult females

SNP	Genotype	Serum 25(OH) D <50 nmol/L N (%)	^aOR (95 % CI)	P value
VDR, rs731236^a	AA	53/65 (81 %)	Ref	-
	AG/GG	72/94 (77 %)	1.57 (0.65–3.78)	0.31
VDR, rs1544410^b	CC	36/45 (80 %)	Ref	-
	CT/TT	92/118 (80 %)	1.72 (0.65–4.54)	0.26
VDR, rs2228570^c	GG	85/107 (79 %)	Ref	-
	GA/AA	43/57 (75 %)	2.07 (0.84–5.09)	0.11
CYP2R1, rs10500804^d	GG	33/44 (75 %)	Ref	-
	GT/ TT	90/115 (78 %)	0.76 (0.30–1.93)	0.57
CYP2R1, rs2060793^e	GG	60/81 (74 %)	Ref	-
	GA /AA	66/79 (83 %)	0.57 (0.21–1.23)	0.13
Cyp2R1, rs10766197^f	AA	28/38 (74 %)	Ref	-
	AG/ GG	98/124 (79 %)	0.83 (0.32–2.15)	0.70
DBP, rs7041^g	AA	29/36 (80 %)	Ref	-
	AC/CC	96/124 (77 %)	1.16 (0.41–3.24)	0.77
DBP, rs4588^h	GG	63/76 (83 %)	Ref	-
	GT /TT	65/88 (74 %)	2.21 (0.89–5.00)	0.09

^aOR odd ratios adjusted for education, sun exposure time, month of recruitment and multivitamin supplementation; SNP, single nucleotide polymorphism, VDR, Vitamin D receptor; DBP, Vitamin D binding protein; CYP2R1, Vitamin D 25-hydroxylase
^an = 159
^bn = 163
^cn = 164
^dn = 159
^en = 160
^fn = 162
^gn = 160
^hn = 164

ISSN: 1472-6874