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Table 2 Characteristics of women accepting or declining to participate in a RCT comparing two different drugs

From: "You can't always get what you want": from doctrine to practicability of study designs for clinical investigation in endometriosis

Characteristics

Accepting RCT

Declining RCT

P

 

n = 50

n = 450

 

Age (years)

39.4 ± 7.3

37.3 ± 7.8

0.07

 

Previous deliveries

22 (44 %)

139 (31 %)

0.08

 

Smoking

3 (6 %)

93 (21 %)

0.013

 

BMI (Kg/m2)

22.6 ± 1.5

23.0 ± 2.5

0.31

 

Education

  

0.45

 

  ≤ 13 years

25 (50 %)

196 (44 %)

  

  > 13 years

25 (50 %)

254 (56 %)

  

Previous surgery for endometriosis

  

0.59

 

 None

19 (38 %)

180 (40 %)

  

 One

24 (48 %)

186 (41 %)

  

  ≥ 2

7 (14 %)

84 (19 %)

  

Previous/current medical treatmentsa

35 (70 %)

319 (71 %)

0.87

 

 Oral Contraceptives

21 (42 %)

193 (43 %)

1.00

 

 Progestins

13 (26 %)

150 (33 %)

0.34

 

 GnRH agonists

1 (2 %)

20 (4 %)

0.71

 

 Non-conventional drugs

6 (12 %)

19 (4 %)

0.03

 

Dysmenorrhea

    

 Biberoglu-Behrman grade 2-3

21 (42 %)

185 (41 %)

1.00

 

 NRS ≥ 8

14 (28 %)

149 (33 %)

0.53

 

Dyspareunia

    

 Biberoglu-Behrman grade 2-3

9 (18 %)

91 (20 %)

0.85

 

 NRS ≥ 8

4 (8 %)

53 (12 %)

0.64

 

Chronic pelvic pain

    

 Biberoglu-Behrman grade 2-3

7 (14 %)

77 (17 %)

0.69

 

 NRS ≥ 8

2 (4 %)

40 (9 %)

0.42

 

Use of analgesics

29 (58 %)

240 (53 %)

0.55

 

 Number of days per monthb

3.9 ± 3.7

4.0 ± 3.3

0.93

 
  1. aThe sum does not add up to the total because some women had used more than one medication
  2. bRefers to those who use analgesics