Table 2 Characteristics of breast cancer molecular subtypes in Eastern Morocco
Characteristics | Luminal A | Luminal B | HER2 | Triple Negative | P-value |
|---|---|---|---|---|---|
(N = 1381) | (N = 364) | (N = 195) | (N = 320) | ||
Percentage of subtypes | 61.1% | 16.1% | 8.6% | 14.2% | Â |
Median age (years) | 48 | 47 | 49 | 45 | 0.038 |
Menopausal status | |||||
 Premenopausal | 55.1% | 62.2% | 64.1% | 72.2% | 0.004 |
 Postmenopausal | 44.9% | 37.8% | 35.9% | 27.8% | |
Histological type | |||||
 Invasive ductal carcinoma | 80,2% | 85,7% | 81,4% | 80% | 0.02 |
 Invasive lobular carcinoma | 15,5% | 8,5% | 14% | 6,3% |  |
 Medullary carcinoma | 0,8% | 0,5% | 0% | 5% |  |
 Mucinous carcinoma | 1,4% | 2,1% | 1,2% | 0,6% |  |
 Papillary carcinoma | 0,9% | 0,5% | 0% | 0% |  |
 Other types | 1,2% | 2,6% | 3,5% | 8,1% |  |
Tumor size | |||||
 Mean size cm ± SD | 3.38 ± 2.1 | 3,42 ± 2.2 | 3.80 ± 2.1 | 3.78 ± 1.9 | 0.097 |
  < 2.0 | 17.3% | 16.7% | 13.8% | 13.2% | 0.005 |
 2.0 – 5.0 | 60.4% | 56.3% | 51.6% | 52.8% | |
  > 5.0 | 22.3% | 27.1% | 34.6% | 34% | |
Histological grade (SBR) | |||||
 I | 16.6% | 8,10% | 4.2% | 5.2% | <0.0001 |
 II | 71.2% | 74.5% | 70.4% | 64.6% | |
 III | 12.2% | 17.4% | 25.4% | 30.2% | |
Vascular emboli status | |||||
 Negative | 32.9% | 27% | 28% | 38.1% | 0.209 |
 Positive | 67.1% | 73% | 72% | 61.9% | |
Lymph node status | |||||
 N0 | 36.1% | 32.9% | 28.6% | 40.8% | 0.114 |
 N+ | 63.9% | 67.1% | 71.4% | 59.2% | |
Metastasis status | |||||
 M0 | 72.4% | 74.5% | 58.1% | 69.9% | 0.059 |
 M+ | 27.6% | 25.5% | 41.9% | 30.1% | |