Table 3 Reproductive factors and their association with breast cancer
From: Reproductive risk factors associated with breast cancer in women in Bangui: a case–control study
Factors associated | Cases (174) N (%) | Controls (348) N (%) | Univariate analysis | Multivariate analysis | ||||
|---|---|---|---|---|---|---|---|---|
COR | 95%, CI [L-U] | p-value | AOR | 95%, CI [L-U] | p-value | |||
Age at menarche (year) | ||||||||
< 12 | 8 (4.6) | 62 (17.8) | 1.00 (Ref) | 1.00 (Ref) | ||||
≥ 12 | 166 (95.4) | 286 (82.2) | 0.22 | [0.10–0.47] | 0.000 | 0.18 | [0.07–0.44] | 0.000 |
Menstrual cycles | ||||||||
Regular | 142 (81.6) | 312 (89.7) | 0.51 | [0.30–0.85] | 0.01 | 0.44 | [0.23–0.81] | 0.009 |
Irregular | 32 (18.4) | 36 (10.3) | 1.00 (Ref) | 1.00 (Ref) | ||||
Term pregnancy | ||||||||
Yes | 143 (82.2) | 319 (91.7) | 0.41 | [0.24–0.72] | 0.002 | 0.26 | [0.13–0.50] | 0.000 |
No | 31 (17.8) | 29 (8.3) | 1.00 (Ref) | 1.00 (Ref) | ||||
Abortion | ||||||||
Yes | 114 (65.5) | 99 (28.4) | 4.77 | [3.23–7.05] | 0.000 | 5.41 | [3.47–8.44] | 0.000 |
No | 60 (34.5) | 249 (71.6) | 1.00 (Ref) | 1.00 (Ref) | ||||
Parity | ||||||||
Nulliparous | 31 (17.9) | 34 (9.8) | 1.76 | [1.02–3.04] | 0.04 | 1.98 | [1.12–3.49] | 0.01 |
1–2 | 46 (26.6) | 128 (36.8) | 0.69 | [0.45–1.05] | 0.69 | 0.76 | [0.49–1.17] | 0.2 |
≥ 3 | 96 (55.5) | 186 (53.4) | 1.00 (Ref) | 1.00 (Ref) | ||||
Mode of Breastfeedinga | ||||||||
Natural | 131 (91.6) | 289 (91.2) | 0.20 | [0.04–0.85] | 0.03 | 0.33 | [0.02–1.15] | 0.43 |
Artificial | 4 (2.8) | 20 (6.3) | 0.45 | [0.16–1.23] | 0.12 | 0.51 | [0.10–2.55] | 0.41 |
Mixed | 8 (5.6) | 8 (2.5) | 1.00 (Ref) | 1.00 (Ref) | ||||
Use of hormonal contraceptive | ||||||||
Yes | 50 (28.9) | 143 (41.1) | 0.58 | [0.39–0.86] | 0.01 | 0.62 | [0.41–0.93] | 0.02 |
No | 123 (71.1) | 205 (58.9) | 1.00 (Ref) | 1.00 (Ref) | ||||
Duration of using hormone contraceptive (year)b | ||||||||
≤ 5 | 36 (72.0) | 103 (72.1) | 1.00 (Ref) | NA | ||||
> 5 | 14 (28.0) | 40 (27.9) | 0.97 | [0.47–1.99] | ||||