Table 3 Comparison of anthropometric, hormonal and lipid parameters and glucose in PCOS and control groups carrying different genotypes of rs1137101
Parameter | Group | rs1137101 genotypes Mean ± SEM | P-value | |||
|---|---|---|---|---|---|---|
AA | AG | GG | ||||
BMI (kg/m2) | PCOS | 30.0 ± 0.75 | 31.0 ± 1.37 | 32.5 ± 1.99 | AA vs. AG | 0.491 |
AA vs. GG | 0.162 | |||||
GG vs. AG | 0.543 | |||||
Control | 26.0 ± 0.72 | 29.4 ± 0.18 | 33.6 ± 2.07 | AA vs. AG | 0.018 | |
AA vs. GG | 0.000 | |||||
GG vs. AG | 0.181 | |||||
W/H ratio | PCOS | 0.84 ± 0.01 | 0.87 ± 0.01 | 0.91 ± 0.029 | AA vs. AG | 0.064 |
AA vs. GG | 0.009 | |||||
GG vs. AG | 0.05 | |||||
Control | 0.75 ± 0.01 | 0.76 ± 0.17 | 0.78 ± 0.016 | AA vs. AG | 0.040 | |
AA vs. GG | 0.119 | |||||
GG vs. AG | 0.252 | |||||
Cholesterol (mmol/L) | PCOS | 4.5 ± 0.11 | 4.35 ± 0.22 | 4.5 ± 023 | AA vs. AG | 0.530 |
AA vs. GG | 1.00 | |||||
GG vs. AG | 0.676 | |||||
Control | 3.57 ± 0.06 | 3.79 ± 0.11 | 3.72 ± 0.121 | AA vs. AG | 0.180 | |
AA vs. GG | 0.313 | |||||
GG vs. AG | 0.718 | |||||
Triglyceride (mmol/L) | PCOS | 1.05 ± 0.05 | 1.34 ± 0.08 | 1.2 ± 0.14 | AA vs. AG | 0.003 |
AA vs. GG | 0.147 | |||||
GG vs. AG | 0.464 | |||||
Control | 0.83 ± 0.04 | 0.92 ± 0.09 | 0.96 ± 0.09 | AA vs. AG | 0.001 | |
AA vs. GG | 0.209 | |||||
GG vs. AG | 0.764 | |||||
HDL (mmol/L) | PCOS | 1.12 ± 0.35 | 0.98 ± 0.03 | 1.07 ± 0.08 | AA vs. AG | 0.040 |
AA vs. GG | 0.613 | |||||
GG vs. AG | 0.248 | |||||
Control | 1.29 ± 0.03 | 1.30 ± 0.07 | 1.12 ± 0.06 | AA vs. AG | 0.080 | |
AA vs. GG | 0.061 | |||||
GG vs. AG | 0.248 | |||||
LDL (mmol/L) | PCOS | 2.55 ± 0.09 | 2.56 ± 0.15 | 2.63 ± 0.16 | AA vs. AG | 0.978 |
AA vs. GG | 0.678 | |||||
GG vs. AG | 0.771 | |||||
Control | 1.69 ± 0.07 | 1.81 ± 0.15 | 1.68 ± 0.13 | AA vs. AG | 0.101 | |
AA vs. GG | 0.989 | |||||
GG vs. AG | 0.570 | |||||
Leptin | PCOS | 28.2 ± 1.67 | 29.8 ± 3.29 | 38.4 ± 5.93 | AA vs. AG | 0.634 |
AA vs. GG | 0.027 | |||||
GG vs. AG | 0.179 | |||||
Control | 22.2 ± 1.78 | 29.3 ± 5.0 | 40.0 ± 6.48 | AA vs. AG | 0.060 | |
AA vs. GG | 0.000 | |||||
GG vs. AG | 0.194 | |||||
Ghrelin | PCOS | 0.39 ± 0.02 | 0.38 ± 0.16 | 0.32 ± 0.13 | AA vs. AG | 0.622 |
AA vs. GG | 0.053 | |||||
GG vs. AG | 0.239 | |||||
Control | 0.49 ± 0.01 | 0.39 ± 0.03 | 0.30 ± 0.02 | AA vs. AG | 0.005 | |
AA vs. GG | 0.000 | |||||
GG vs. AG | 0.042 | |||||
Insulin (pmol/L) | PCOS | 110.8 ± 7.7 | 107.4 ± 10.77 | 92.60 ± 14.06 | AA vs. AG | 0.794 |
AA vs. GG | 0.270 | |||||
GG vs. AG | 0.412 | |||||
Control | 66.7 ± 4.03 | 80.8 ± 7.33 | 95.4 ± 10.5 | AA vs. AG | 0.110 | |
AA vs. GG | 0.005 | |||||
GG vs. AG | 0.247 | |||||
Fasting glucose | PCOS | 5.09 ± 0.06 | 5.07 ± 0.08 | 5.04 ± 0.143 | AA vs. AG | 0.828 |
AA vs. GG | 0.723 | |||||
GG vs. AG | 0.874 | |||||
Control | 4.66 ± 0.05 | 4.63 ± 0.12 | 5.06 ± 0.12 | AA vs. AG | 0.522 | |
AA vs. GG | 0.002 | |||||
GG vs. AG | 0.012 | |||||
HOMA-IR | PCOS | 3.61 ± 1.74 | 3.51 ± 1.85 | 3.04 ± 0.489 | AA vs. AG | 0.788 |
AA vs. GG | 0.274 | |||||
GG vs. AG | 0.448 | |||||
Control | 2.04 ± 0.13 | 2.44 ± 0.24 | 3.16 ± 0.37 | AA vs. AG | 0.139 | |
AA vs. GG | 0.002 | |||||
GG vs. AG | 0.110 | |||||