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Table 3 Comparison of anthropometric, hormonal and lipid parameters and glucose in PCOS and control groups carrying different genotypes of rs1137101

From: The influence of the rs1137101 genotypes of leptin receptor gene on the demographic and metabolic profile of normal Saudi females and those suffering from polycystic ovarian syndrome

Parameter Group rs1137101 genotypes Mean ± SEM P-value
AA AG GG
BMI (kg/m2) PCOS 30.0 ± 0.75 31.0 ± 1.37 32.5 ± 1.99 AA vs. AG 0.491
AA vs. GG 0.162
GG vs. AG 0.543
Control 26.0 ± 0.72 29.4 ± 0.18 33.6 ± 2.07 AA vs. AG 0.018
AA vs. GG 0.000
GG vs. AG 0.181
W/H ratio PCOS 0.84 ± 0.01 0.87 ± 0.01 0.91 ± 0.029 AA vs. AG 0.064
AA vs. GG 0.009
GG vs. AG 0.05
Control 0.75 ± 0.01 0.76 ± 0.17 0.78 ± 0.016 AA vs. AG 0.040
AA vs. GG 0.119
GG vs. AG 0.252
Cholesterol (mmol/L) PCOS 4.5 ± 0.11 4.35 ± 0.22 4.5 ± 023 AA vs. AG 0.530
AA vs. GG 1.00
GG vs. AG 0.676
Control 3.57 ± 0.06 3.79 ± 0.11 3.72 ± 0.121 AA vs. AG 0.180
AA vs. GG 0.313
GG vs. AG 0.718
Triglyceride (mmol/L) PCOS 1.05 ± 0.05 1.34 ± 0.08 1.2 ± 0.14 AA vs. AG 0.003
AA vs. GG 0.147
GG vs. AG 0.464
Control 0.83 ± 0.04 0.92 ± 0.09 0.96 ± 0.09 AA vs. AG 0.001
AA vs. GG 0.209
GG vs. AG 0.764
HDL (mmol/L) PCOS 1.12 ± 0.35 0.98 ± 0.03 1.07 ± 0.08 AA vs. AG 0.040
AA vs. GG 0.613
GG vs. AG 0.248
Control 1.29 ± 0.03 1.30 ± 0.07 1.12 ± 0.06 AA vs. AG 0.080
AA vs. GG 0.061
GG vs. AG 0.248
LDL (mmol/L) PCOS 2.55 ± 0.09 2.56 ± 0.15 2.63 ± 0.16 AA vs. AG 0.978
AA vs. GG 0.678
GG vs. AG 0.771
Control 1.69 ± 0.07 1.81 ± 0.15 1.68 ± 0.13 AA vs. AG 0.101
AA vs. GG 0.989
GG vs. AG 0.570
Leptin PCOS 28.2 ± 1.67 29.8 ± 3.29 38.4 ± 5.93 AA vs. AG 0.634
AA vs. GG 0.027
GG vs. AG 0.179
Control 22.2 ± 1.78 29.3 ± 5.0 40.0 ± 6.48 AA vs. AG 0.060
AA vs. GG 0.000
GG vs. AG 0.194
Ghrelin PCOS 0.39 ± 0.02 0.38 ± 0.16 0.32 ± 0.13 AA vs. AG 0.622
AA vs. GG 0.053
GG vs. AG 0.239
Control 0.49 ± 0.01 0.39 ± 0.03 0.30 ± 0.02 AA vs. AG 0.005
AA vs. GG 0.000
GG vs. AG 0.042
Insulin (pmol/L) PCOS 110.8 ± 7.7 107.4 ± 10.77 92.60 ± 14.06 AA vs. AG 0.794
AA vs. GG 0.270
GG vs. AG 0.412
Control 66.7 ± 4.03 80.8 ± 7.33 95.4 ± 10.5 AA vs. AG 0.110
AA vs. GG 0.005
GG vs. AG 0.247
Fasting glucose PCOS 5.09 ± 0.06 5.07 ± 0.08 5.04 ± 0.143 AA vs. AG 0.828
AA vs. GG 0.723
GG vs. AG 0.874
Control 4.66 ± 0.05 4.63 ± 0.12 5.06 ± 0.12 AA vs. AG 0.522
AA vs. GG 0.002
GG vs. AG 0.012
HOMA-IR PCOS 3.61 ± 1.74 3.51 ± 1.85 3.04 ± 0.489 AA vs. AG 0.788
AA vs. GG 0.274
GG vs. AG 0.448
Control 2.04 ± 0.13 2.44 ± 0.24 3.16 ± 0.37 AA vs. AG 0.139
AA vs. GG 0.002
GG vs. AG 0.110