Fig. 3

Changes (%) in the bleeding pattern from baseline to 6-months (6 mo.) visits. The bleeding patterns were defined as follows: 1) Normal bleeding: Regular bleeding with normal flow and duration. 2) Irregular bleeding cycle: Bleeding cycle less than 21 days or more than 35 days. 3) Amenorrhea: No menstruation during last 90 days. 4) Intermenstrual spotting / bleeding: Irregular episodes of bleeding, often light and short, occurring between otherwise fairly normal menstrual periods. Normal bleeding decreased from 84.2% at baseline to 28.8% after 6 months. Irregular bleeding cycle increased from 7.6 to 10.2%, amenorrhea from 3.2 to 42.9%, intermenstrual bleeding/spotting from 2.3 to 15.1%.