Fig. 2

a. Changes in hemoglobin levels, white blood cell counts, platelets counts and levels of antithrombin 3. At 3 days after the procedure, the hemoglobin (Hb) level and the platelet count was slightly decreased from the initial data. The white blood cell (WBC) count and the level of antithrombin 3 (AT3) was in normal range. At fifth day of post procedure, the Hb level was decreased and the platelet count was markedly decreased. The WBC count was markedly increased although the level of AT3 was still in normal range. After the treatment of nafamostat mesylate and cefmetazole, the data were recovered. b. Changes in levels of D-dimer, thrombin antithrombin3 complex, plasminogen activator inhibitor-1 and plasminα2-plasmin inhibitor complex. The level of plasminogen activator inhibitor-1 (PAI-1) and the level of thrombin antithrombin 3 complex (TAT) was increased by the third day after the procedure, while the level of D-dimer and the level of plasminα2-plasmin inhibitor complex (PIC) were in normal range. The levels of D-dimer, TAT and PIC increased markedly on the fifth day although the level of PAI-1 started to decease. Treatment with nafamostat mesilate led to rapid improvement of the levels of D-dimer, TAT and PIC