Fig. 2

Computed tomography (CT) images showing the effect of pazopanib (800 mg/day). The upper, middle, and lower lines indicate chest CT, liver CT, and pelvic CT, respectively. The left, central, and right rows indicate before administration of pazopanib, 12 weeks later, and 24 weeks later, respectively. Red arrows and green arrows indicate tumors, and common bile duct stents, respectively. Chest CT images show that lung metastases reduced after 12 weeks of treatment and recurred after 24 weeks, in comparison with the first scan. Liver CT images show that liver metastatic tumors reduced and liquefied, while continuing the administration of pazopanib. Pelvic CT images show that the right pelvic dissemination tumor reduced, and there was a decrease in ascites after 12 weeks of treatment and an increase in ascites 24 weeks later