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Table 4 Safety outcomes (Intention-to-treat analysis, n = 67) a

From: Effects of vaginal administration of conjugated estrogens tablet on sexual function in postmenopausal women with sexual dysfunction: a double-blind, randomized, placebo-controlled trial

Parameter

Estrogens group*

(n = 34)

Placebo group

(n = 33)

P-value

Week 0

Week 12

Week 0

Week 12

Hematocrit (%)a

39.42 ± 3.30

38.68 ± 2.51

39.36 ± 3.23

38.63 ± 3.06

0.655

SGOT (unit/L)a

28.72 ± 12.05

27.10 ± 15.48

23.79 ± 9.72

24.96 ± 9.62

0.390

SGPT (unit/L)a

29.86 ± 16.90

30.31 ± 20.95

24.33 ± 14.03

29.33 ± 15.74

0.279

ALP (unit/L)a

77.07 ± 29.42

76.69 ± 22.15

77.75 ± 20.91

79.38 ± 18.25

0.809

Total cholesterol (mg/dL)a

215.72 ± 37.62

212.93 ± 38.03

215.04 ± 39.35

218.00 ± 38.20

0.733

Triglycerides (mg/dL)a

123.69 ± 45.37

114.93 ± 52.79

126.71 ± 64.49

162.33 ± 97.69

0.045

HDL (mg/dL)a

57.21 ± 10.52

58.72 ± 12.75

56.63 ± 11.91

54.29 ± 11.41

0.142

LDL (mg/dL)a

134.00 ± 34.56

131.17 ± 33.37

133.13 ± 36.19

131.21 ± 39.52

0.825

Endometrial thickness (mm)a

3.28 ± 2.03

3.38 ± 1.97

3.44 ± 2.30

3.15 ± 1.72

0.677

Estradiol (pg/mL)b

5.00 (5.00,11.94)

5.00 (5.00,9.61)

5.00 (5.00,12.96)

5.00 (5.00,9.89)

0.218

  1. *conjugated estrogens
  2. amean ± SD Data was analyzed by ANCOVA,
  3. bmedian (interquartile range, IQR) Data was analyzed by Mann-Whitney U test
  4. Data shown in bold indicates statistical significance (p < 0.05)