Table 4 Mean Changes in Outcomes Measures; Low vs High Risk Women, Adjusted for Treatment Effects
Changes in Outcome Measures from Baseline; Low vs. High Risk | 3 Months | 6 Months | 9 Months | 12 Months | ||||
|---|---|---|---|---|---|---|---|---|
β (95% CI) | p-value | β (95% CI) | p-value | β (95% CI) | p-value | β (95% CI) | p-value | |
Changes in SBP relative to baseline | ||||||||
 Low risk | −17.87 (− 20.53, − 15.23) | <  0.01** | −17.87 (− 20.51, − 15.24) | <  0.01** | −16.53 (− 19.17, − 13.88) | <  0.01** | − 17.92 (− 20.56, − 15.28) | <  0.01** |
 High risk | −17.87 (− 20.34, − 15.40) | <  0.01** | −17.87 (− 20.38, − 15.36) | <  0.01** | −16.19 (− 18.69, − 13.68) | <  0.01** | −19.48 (− 21.99, − 16.97) | <  0.01** |
Change between (ref: Low risk) | ||||||||
 High risk | 0.006 (− 1.32, 1.33) | 0.98 | 0.009 (− 1.29, 1.30) | 0.99 | 0.34 (− 1.01, 1.69) | 0.62 | − 1.55 (− 2.92, − 0.18) | 0.03* |
Changes in DBP relative to baseline | ||||||||
 Low risk | −8.49 (− 10.63, − 6.35) | <  0.01** | − 10.17 (− 12.28, − 8.05) | <  0.01** | − 9.25 (− 11.38, − 7.13) | <  0.01** | − 9.49 (− 11.62, − 7.37) | <  0.01** |
 High risk | −9.97 (− 11.97, − 7.98) | <  0.01** | −9.84 (− 11.87, − 7.82) | <  0.01** | −9.31 (− 11.33, − 7.28) | <  0.01** | − 10.12 (− 12.15, − 8.10) | <  0.01** |
Change between (ref: Low risk) | ||||||||
 High risk | −1.57 (− 2.60, − 0.54) | <  0.01** | 0.24 (− 0.78, 1.25) | 0.65 | − 0.14 (− 1.20, 0.92) | 0.79 | − 0.72 (− 1.79, 0.35) | 0.19 |
Changes in BSR relative to baseline | ||||||||
 Low risk | −7.13 (− 18.65, 4.40) | 0.23 | −1.81 (− 13.31, 9.68) | 0.76 | − 8.75 (− 20.25, 2.76) | 0.14 | − 11.17 (− 22.67, 0.34) | 0.06 |
 High risk | −10.16 (−20.86, 0.53) | 0.06 | − 7.00 (− 17.91, 3.90) | 0.21 | − 11.30 (− 22.17, − 0.43) | 0.04* | −13.06 (− 23.95, −2.17) | 0.02* |
Change between (ref: Low risk) | ||||||||
 High risk | 0.98 (− 4.99, 6.95) | 0.75 | −1.17 (− 7.07, 4.73) | 0.70 | 1.46 (− 4.67, 7.59) | 0.64 | 2.12 (− 4.09, 8.34) | 0.50 |
Changes in Urea relative to baseline | ||||||||
 Low risk | 1.06 (−0.81, 2.93) | 0.27 | 2.49 (0.62, 4.35) | 0.01* | 2.04 (0.18, 3.91) | 0.03* | 2.83 (0.97, 4.70) | < 0.01** |
 High risk | 1.00 (−0.73, 2.73) | 0.26 | 2.27 (0.50, 4.03) | 0.01* | 2.09 (0.33, 3.85) | 0.02* | 2.51 (0.75, 4.28) | 0.01* |
Change between (ref: Low risk) | ||||||||
 High risk | 0.07 (−0.90, 1.04) | 0.89 | −0.09 (−1.05, 0.87) | 0.86 | 0.18 (−0.82, 1.17) | 0.73 | −0.19 (− 1.20, 0.82) | 0.71 |
Changes in Creatinine relative to baseline | ||||||||
 Low risk | 0.01 (−0.04, 0.06) | 0.77 | 0.01 (−0.04, 0.07) | 0.58 | 0.05 (0.004, 0.11) | 0.04* | 0.07 (0.02, 0.12) | 0.01* |
 High risk | 0.01 (−0.02, 0.03) | 0.57 | 0.03 (−0.01, 0.08) | 0.17 | 0.03 (−0.02, 0.08) | 0.26 | 0.06 (0.01, 0.11) | 0.01* |
Change between (ref: Low risk) | ||||||||
 High risk | 0.008 (−0.02, 0.03) | 0.57 | 0.01 (−0.01, 0.04) | 0.40 | −0.03 (− 0.06, − 0.01) | 0.01* | −0.01 (− 0.04, 0.01) | 0.36 |